Publications by authors named "Olga Carofiglio"
Article Synopsis
- Research shows that despite current prevention methods, early recurrent strokes are still common, especially in patients with atherosclerosis, with over 10% experiencing repeat events.
- A new mouse model revealed that strokes activate the AIM2 inflammasome in atherosclerotic plaques due to increased circulating cell-free DNA, leading to inflammation, plaque destabilization, and recurrent strokes.
- Targeting the mechanisms of DNA-mediated inflammasome activation may offer new treatment options to reduce the high rate of recurrent strokes in at-risk patients.
Article Synopsis
- - Chronic comorbidities following a stroke contribute significantly to patient health, and this study investigates how immune system changes may play a role in these issues.
- - Researchers discovered that the immune response, particularly in monocytes/macrophages, remains persistently pro-inflammatory in various organs, especially the heart, even months after a stroke.
- - Targeting IL-1β and blocking certain immune cell movement successfully prevented heart dysfunction in a study, suggesting potential new therapies for managing post-stroke complications.
Article Synopsis
- - The study highlights the unique molecular characteristics of bone marrow in the skull, contrasting it with other bones and demonstrating its significant role in immune responses within the brain and meninges.
- - Researchers found that mouse skull marrow exhibits a distinct transcriptomic profile, particularly in relation to neutrophils, and similar proteomic differences were observed in human skull marrow.
- - Advanced imaging techniques reveal the structural connections between the skull and meninges, and the skull marrow's inflammatory response correlates with neurological disorders, suggesting its potential in diagnosing and treating brain diseases.
Neuroinflammation is an emerging focus of translational stroke research. Preclinical studies have demonstrated a critical role for brain-invading lymphocytes in post-stroke pathophysiology. Reducing cerebral lymphocyte invasion by anti-CD49d antibodies consistently improves outcome in the acute phase after experimental stroke models.
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