High Doses of Pesticides Induce mtDNA Damage in Intact Mitochondria of Potato In Vitro and Do Not Impact on mtDNA Integrity of Mitochondria of Shoots and Tubers under In Vivo Exposure.

It is well known that pesticides are toxic for mitochondria of animals. The effect of pesticides on plant mitochondria has not been widely studied. The goal of this research is to study the impact of metribuzin and imidacloprid on the amount of damage in the mtDNA of potato ( L.

The effect of pesticides on the mtDNA integrity and bioenergetic properties of potato mitochondria.

Potato (Solanum tuberosum L.) is one of the most common crops in the world, and it is very susceptible to a wide range of pests such as insects and fungi. The use of pesticides often results in the suppression of seed germination and plant growth, in particular, due to their effect on the respiratory chain of mitochondria.

Cladribine tablets' potential role as a key example of selective immune reconstitution therapy in multiple sclerosis.

Multiple sclerosis (MS) is one of the most important, disabling, and prevalent neurological disorders of young adults. It is a chronic inflammatory and neurodegenerative disease when autoreactive B and T cells have downstream effects that result in demyelination and neuronal loss. Anti-inflammatory disease-modifying therapies do have proven efficacy in delaying disease and disability progression in MS.

New insights into the burden and costs of multiple sclerosis in Europe: Results for Russia.

Background: In order to assess the value of management strategies in multiple sclerosis (MS), outcome data have to be combined with cost data. This, in turn, requires that cost data be regularly updated.

Objective And Methods: This study is part of a cross-sectional retrospective study in 16 countries collecting current data on resource consumption, work capacity and health-related quality of life (HQoL).

Experimental demonstration of ultrasharp unpolarized filtering by resonant gratings at oblique incidence.

The peaks in the reflectivity spectrum of waveguide gratings observed when the incident beam couples to a mode of the structure are promising features for many applications. However their weak angular tolerance and their strong polarization sensitivity, especially under oblique incidence, limit their interest in practice. These problems can be overcome by forming slow degenerate modes outside the usual high symmetry points of the Brillouin zone with a complex periodic pattern [Fehrembach, Appl.

Experimental demonstration of a narrowband, angular tolerant, polarization independent, doubly periodic resonant grating filter.

Resonant grating filters are promising components for free-space narrowband filtering. Unfortunately, due to their weak angular tolerance, their performances are strongly deteriorated when they are illuminated with a standard collimated beam. Yet this problem can be overcome by resorting to a complex periodic pattern known as the doubly periodic grating [Lemarchand et al.

Design and characterization of extreme-ultraviolet broadband mirrors for attosecond science.

A novel multilayer mirror was designed and fabricated based on a recently developed three-material technology aimed both at reaching reflectivities of about 20% and at controlling dispersion over a bandwidth covering photon energies between 35 and 50 eV. The spectral phase upon reflection was retrieved by measuring interferences in a two-color ionization process using high-order harmonics produced from a titanium: sapphire laser. We demonstrate the feasibility of designing and characterizing phase-controlled broadband optics in the extreme-ultraviolet domain, which should facilitate the manipulation of attosecond pulses for applications.