Publications by authors named "Olga B Glavnova"
Background: The most common cause of hyperandrogenism in women is polycystic ovary syndrome (PCOS), the prevalence of which among women of reproductive age ranges from 8.0 to 21%. The clinical manifestations of PCOS are diverse, and the degree of metabolic and hormonal disorders depends on the PCOS phenotype.
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- Metformin is commonly used to treat type 2 diabetes, but individual responses to the drug can vary significantly, potentially due to genetic differences.
- A study analyzed the effects of specific genetic variants on metformin response in 299 patients, identifying the rs12208357 variant as significantly impacting treatment outcomes.
- Machine learning models incorporating genetic and clinical factors, like gender and body measurements, were developed to better predict metformin response, showing potential for personalized diabetes treatment approaches.