Publications by authors named "Olfa Khayat"

Article Synopsis
  • Erythrokeratodermia variabilis (EKV) is a rare skin disorder linked to mutations in the GJB3 and GJB4 genes but can also occur due to other genetic mutations as seen in a consanguineous Tunisian family.
  • Whole-exome sequencing identified a new homozygous mutation in the NIPAL4 gene in two sisters, suggesting it plays a critical role in this specific EKV phenotype.
  • The younger sister displayed signs of Autosomal Recessive Congenital Ichthyosis, highlighting the variability of symptoms in EKV and reinforcing the importance of studying the NIPAL4 gene's impact on skin barrier function.
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Introduction: Anguillulosis is a ubiquitous digestive parasitosis. Rare in Tunisia, it is due to a round worm, strongyloid stercoralis, whose natural lodging is the duodeno-jejunal mucosa. Its malignant form is rare but it represents a potentially life-threatening disease.

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Neuroblastoma-like schwannoma (NLS) is a rare variant of a common tumor. The aim of this study is to discuss, through a literature review, the differential diagnoses of NLS while emphasizing the importance of ancillary studies. So far, 24 cases have been reported.

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Intranodal palisaded myofibroblastoma (IPM), also known as "intranodal hemorrhagic spindle cell tumor with amianthoid fibers," is a rare benign mesenchymal tumor originating from smooth muscle cells and myofibroblasts, often with the presence of amianthoid fibers. Usually IPM affects inguinal lymph nodes, but three cases have been described in the submandibular and cervical lymph nodes. We report a new case of a 44-year-old women with submandibular mass.

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Oncocytic metaplasia of the nasopharynx is an exceptional lesion which exact etiopathogenesis, although largely discussed, still remains controversial. The purpose of this paper is to present the epidemiological characteristics and clinical signs of this lesion and to study its pathogenesis and its therapeutic modalities. We report two cases that occurred respectively in a 53- and 60-year-old woman.

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Background: The salivary gland tumors are rare (less than 3% of all tumors) and poorly known. In fact, they are numerous and histologically difficult to diagnose.

Aim: This work aims to point at the different histological types of salivary gland tumors, to draw out the principal epidemiological, clinical, radiological and histological characteristics, and to compare our cases to those of the literature.

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Article Synopsis
  • The study aimed to find out what factors lead to fat accumulation (steatosis) in patients with chronic hepatitis B and how this might affect liver fibrosis and relate to viral factors in a Tunisian patient group.
  • Researchers included 44 patients with confirmed chronic hepatitis B and examined various health metrics, including age, body mass index, and cholesterol levels, to see their correlation with steatosis.
  • Results showed that 34.1% of patients had steatosis, with significant predictors being higher body mass index and cholesterol levels, but steatosis did not appear to influence liver fibrosis or relate to the viral status of the patients.
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Background: Sarcoidosis is an ubiquity disease, which can infiltrate all tissues. The cutaneous and ophthalmologic thoracic localizations are most frequent. The nasosinusienne localisation is rare.

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Background: Sneddon-Wilkinson disease (SW) is chronic and benign disease belonging to the heterogeneous spectrum of neutrophilic diseases. It is characterised by flask, superficial, aseptic pustules, mainly involving the trunk, axilla and inguinal folds, favourably responsive to sulfones.

Aim: We report an original case with an atypical clinical presentation and course.

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The plexiform fibrohistiocytic tumor is rare. It affects mainly children and adolescent. This tumor occurs at the dermo-subcutaneous region of the upper extremities.

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It's a prospective study leaded between September 1997 and july 1999 (23 months ) in 75 patients with duodenal ulcer and positif for Helicobacter pylori. All patients had a first endoscopy with antral, fundic and duodenal biopsies, followed one month later by a second control fibroscopy with biopsies of the same sites. A total of 420 biopsies was realised.

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Peutz-Jeghers syndrome is a hereditary affection with dominant autosomal transmission. The risk of cancerisation is largely higher than that in the general population. Dysplasia is rare.

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GI stromal tumors are mesenchymatal tumors arising primarily from the digestive tract or from the omentum. Despite their rarity (less than 1% of digestive tumors). These tumors have become of current interest since the discovery of a treatment for metastatic and locally advanced tumors, the imatinib (Glivec).

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Angiomatoid fibrous histiocytoma is a rare tumour affecting young adults. Unlike conventional malignant fibrous histiocytoma, its extension is only local thus giving a good prognosis. We report the cases of a 9 year-old girl and a 16 year-old boy presenting respectively, with an axillary tumour 5 cm of diameter and a paravertebral subcutaneous tumour 1.

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Extrahepatic bile ducts carcinoma (EHBC) arises usually in the upper third of the biliary tract. They are rarely multicentric associated or not to a gallbladder carcinoma. We report the case of a 53 years man operated for a head pancreas.

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Sarcoidosis is a disseminated disease defined by the presence of non-caseous granulomas. Digestive localizations are rare and the stomach is the mostly affected. The diagnosis is frequently difficult.

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Objectives: To assess the effet of cryopreservation on the structural and functional properties of venous and arterial human allografts.

Materials And Methods: Segments of arteries and veins harvested from multiorgan donors were divided into 3 groups: fresh-control tested for 24 hours after harvesting, frozen directly at -80 degrees C and frozen gradually (progressive freezing technique) and preserved in liquid nitrogen at -196 degrees C degree. The 2 cryopreserved groups of segments were allowed in two different cryoprotectant solutions (M1 and M2) containing both dimethyl sulphoxide (10%), RPMI 1640 for the first and M 199 for the second.

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