Publications by authors named "Olexandr V Ogloblya"
Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate.
ScientificWorldJournal
November 2017
Article Synopsis
- The protein kinase inhibitor MI-1 showed promising anti-inflammatory effects in a rat model of acetic acid-induced ulcerative colitis, outperforming the reference drug Prednisolone in reducing tissue damage.
- After 14 days of treatment, MI-1 significantly improved colon mucosa integrity, with a grade of total injury (GTI) falling to 0.5 compared to 3 for Prednisolone.
- Additionally, MI-1 effectively normalized oxidative stress markers in the bowel, suggesting its potential for treating inflammatory diseases better than current standard therapies.