PROGNOSTIC VALUES OF LIPID PANEL DATA FOR MACROVASCULAR COMPLICATION DEVELOPMENT IN TYPE 2 DIABETIC PATIENTS WITH COMORBID THYROID DYSFUNCTION.

This study aimed to evaluate prognostic values of the serum lipid panel data for development of macrovascular complications (MVC) in patients with type 2 diabetes mellitus (T2DM) alone and those with comorbid hypothyroidism (HT), diffuse non-toxic goiter (DNTG), or a combination of these disorders. The study included 596 inpatients. Receiver operating characteristic (ROC) analysis was used to identify prognostically significant values of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non-HDL-cholesterol (non-HDL-C) and remnant cholesterol (RC).

Morphometric assessment of the structural remodeling of endothelial cells in the arterial and venous systems of the testes in experimental animals under ethanol intoxication.

Objective: Aim: Using morphometric methods to study the features of endotheliocyte remodeling of the arterial and venous beds of the testicles during long-term ethanol intoxication.

Patients And Methods: Materials and Methods: Endotheliocytes of the arterial and venous bed of the left and right testes of 60 white male rats, which were divided into two groups, were morphologically studied. The 1 group consisted of 30 intact animals, the 2 - 30 rats, which were daily intragastrically injected with a 30 % ethanol solution at the rate of 2 ml per 100 g of the animal's weight for 28 days.

Indicators of oxidative stress in the organs of the reproductive system of rats under conditions of long-term ethanol exposure.

Objective: . Aim: To investigate changes in oxidative stress indicators in rats under conditions of long-term ethanol exposure.

Patients And Methods: Materials and Methods: We studied the effect of prolonged exposure to ethanol on the activity of free radical processes in the gonads of rats of both sexes.

Quantitative morphological analysis of age structural changes in prostate of experimental animals with ethanol poisoning.

Objective: Aim: To find out the age remodeling of the structural components of the prostate gland at alcohol poisoning using quantitative morphological analysis.

Patients And Methods: Materials and Methods: The structure of the prostate gland of 4 white male rats groups were morphologically investigated. The 1 group included 30 control intact animals aged 8 months, the 2-nd group - 30 rats aged 24 months, the 3-rd group - 30 8-month-old animals with ethanol intoxication, and the 4-th group included 30 24-month-old rats with the specified simulated pathology.

QUANTITATIVE MORPHOLOGICAL FEATURES OF THE STRUCTURAL REARRANGEMENT OF THE VENOUS BLOOD VESSELS OF THE PROSTATE GLAND IN POST-RESECTION PORTAL HYPERTENSION.

Objective: Aim: Using quantitative morphological methods to study the peculiarities of the structural reconstruction of the venous bad of the prostate at the conditions of post-resection portal hypertension.

Patients And Methods: Materials and Methods: Morphologically, the venous bed of the prostate of 15 intact white rats, 30 animals with post-resection portal hypertension, 17 rats with a combination of post-resection portal hypertension with hepatargia, enteral, cardiac, and renal insufficiency was studied. Rats were slaughtered one month after the start of the experiment by bloodletting under general thiopental anesthesia.

Functionalization of Carbon Nanomaterial Surface by Doxorubicin and Antibodies to Tumor Markers.

The actual task of oncology is effective treatment of cancer while causing a minimum harm to the patient. The appearance of polymer nanomaterials and technologies launched new applications and approaches of delivery and release of anticancer drugs. The goal of work was to test ultra dispersed diamonds (UDDs) and onion-like carbon (OLCs) as new vehicles for delivery of antitumor drug (doxorubicin (DOX)) and specific antibodies to tumor receptors.

Effect of single-walled carbon nanotubes on tumor cells viability and formation of multicellular tumor spheroids.

Abstract: This paper describes the impact of different concentrations of single-walled carbon nanotubes (SWCNTs) on cell viability of breast adenocarcinoma, MCF-7 line, and formation of multicellular tumor spheroids (MTS). Chemical composition and purity of nanotubes is controlled by Fourier transform infrared spectroscopy. The strength and direction of the influence of SWCNTs on the tumor cell population was assessed by cell counting and measurement of the volume of multicellular tumor spheroids.