Novel N-Cycloalkylcarbonyl-N'-arylthioureas: Synthesis, Design, Antifungal Activity and Gene Toxicity.

A synthesis method of novel N-cycloalkylcarbonyl-N'-arylthioureas was developed. It consists of sequential addition of equimolecular amounts of ammonium isothiocyanate and substituted anilines to cycloalkylcarbonyl chlorides. The identity and purity of products were confirmed by LC/MS spectra, their structure by elemental analysis, IR and H-NMR spectra.