Publications by authors named "Olena Potapenko"

Article Synopsis
  • Metformin, a diabetes medication, appears to offer cardiovascular protection and influences gut microbiota in hypertensive rats.
  • In the study, metformin treatment increased short-chain fatty acids (SCFAs) in feces, lowered blood pressure, and improved cardiac function, despite some increase in cardiac hypertrophy.
  • The research suggests that SCFA levels may mediate the observed anti-inflammatory and blood pressure-lowering effects of metformin, even in the absence of diabetes.
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Background: Peanut allergy is a frequent cause of food allergy and potentially life-threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non-allergic controls.

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Rationale: Antibiotic treatment of patients infected with G(-) or G(+) bacteria promotes release of the toxins lipopolysaccharide (LPS) and pneumolysin (PLY) in their lungs. Growth Hormone-releasing Hormone (GHRH) agonist JI-34 protects human lung microvascular endothelial cells (HL-MVEC), expressing splice variant 1 (SV-1) of the receptor, from PLY-induced barrier dysfunction. We investigated whether JI-34 also blunts LPS-induced hyperpermeability.

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