Epigallocatechin-3-gallate prevents disruption of connective tissue in periodontium and salivary glands of rats during systemic inflammation.

Objective: Introduction: The connective tissue remodeling is essential for periodontal and salivary glands (SG) pathology. Recently there has been demonstrated the number of pharmacological effects of green tea (Camellia sinensis) such as antioxidant, anti-inflammatory, anti-aging, antibacterial, antiviral and DNA-protective effects, associated with the presence of epigallocatechin-3-gallate (EGCG) as an inducer of the Keap1 / Nrf2 / antioxidant response element signaling pathway. However, the EGCG effects on the components of soft connective tissues of periodontium and SG are still unclear.