FEATURES OF SKIN WOUNDS HEALING UNDER CHRONIC HYPERGLYCEMIA AND IMPROVEMENT OF THEIR TREATMENT METHODS.

Objective: The aim: The work was aimed to study the histological, morphometric and planimetric features of skin regeneration in mature rats with chronic hyperglycemia under the influence of platelet-rich plasma.

Patients And Methods: Materials and methods: 60 mature white laboratory rats were used. The animals were divided into three groups (I - control with mechanical skin injuries; II - rats with chronic hyperglycemia and modeled mechanical skin injuries; III - animals with the chronic hyperglycemia and modeled mechanical skin injuries which were injected with the platelet-rich plasma).

Improvement of Skeletal Muscle Regeneration by Platelet-Rich Plasma in Rats with Experimental Chronic Hyperglycemia.

Herein, the structural effect of autologous platelet-rich plasma (PRP) on posttraumatic skeletal muscle regeneration in rats with chronic hyperglycemia (CH) was tested. 130 white laboratory male rats divided into four groups (I-control; II-rats with CH; III-rats with CH and PRP treatment; and IV-rats for CH confirmation) were used for the experiment. CH was simulated by streptozotocin and nicotinic acid administration.