Efficacy of evaluation of microRNA-122 and microRNA-21 levels in the role of biomarkers of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis.

Aim: The aim of this study was to evaluate the efficacy of determining the microRNA-122 and microRNA-21 expression levels in serum and bile as predictors of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis.

Materials And Methods: The study included 32 patients who were divided into two groups: I - study group and II - comparison group. The study group included patients with acute calculous cholecystitis (ACC) and oligosymptomatic choledocholithiasis (OCL) (n=23), and the comparison group consisted of patients with ACC without choledocholithiasis (n=9).

Perspective for evaluation of microrna in plasma and bile for differential diagnosis of obstructive biliary tract disease.

Objective: Introduction: Cholelithiasisis diagnosed in 10-25% of the adult population. The manifestation of cholelithiasis in the form of acute cholecystitis, cholangitis, jaundice etc. occurs with a probability of 2-3% or more per year depending on the risk factors.