Publications by authors named "Oleksandr Moroz"
Adv Healthc Mater
November 2024
Article Synopsis
- - Cartilage endplate cell (CEPC) and nucleus pulposus cell (NPC) inflammation play a crucial role in intervertebral disc degeneration (IVDD), with iron ions and reactive oxygen species (ROS) being significant contributors to this process.
- - A new composite gel, CAP-sEXOs@Gel, has been developed, which uses engineered exosomes loaded with salvianolic acid A to target CEPCs and release them slowly, while also neutralizing the acidic environment to alleviate NPC inflammation.
- - The CAP-sEXOs@Gel effectively reduces intracellular iron and ROS levels, helping maintain mitochondrial function in CEPCs and suppressing inflammatory pathways, indicating its potential as a therapeutic strategy for reversing IVDD.
