Microbiological aspects of conservative treatment of periodontal disease using gel-based preparations.

Unlabelled: The results of epidemiological studies as well as statistical data show that in recent years the dental morbidity rate in the world has remained stable at a high level. Inflammatory diseases of periodontal tissues, in particular generalized forms of periodontitis, reach 80% in the world. The tendency of increasing the prevalence rate of these diseases in Ukraine, 60-99%, is being observed nowadays.

Improving ED Emergency Severity Index Acuity Assignment Using Machine Learning and Clinical Natural Language Processing.

Introduction: Triage is critical to mitigating the effect of increased volume by determining patient acuity, need for resources, and establishing acuity-based patient prioritization. The purpose of this retrospective study was to determine whether historical EHR data can be used with clinical natural language processing and machine learning algorithms (KATE) to produce accurate ESI predictive models.

Methods: The KATE triage model was developed using 166,175 patient encounters from two participating hospitals.

Clb3-centered regulations are recurrent across distinct parameter regions in minimal autonomous cell cycle oscillator designs.

Some biological networks exhibit oscillations in their components to convert stimuli to time-dependent responses. The eukaryotic cell cycle is such a case, being governed by waves of cyclin-dependent kinase (cyclin/Cdk) activities that rise and fall with specific timing and guarantee its timely occurrence. Disruption of cyclin/Cdk oscillations could result in dysfunction through reduced cell division.

Youth smoking and anti-smoking policies in North Dakota: a system dynamics simulation study.

Background: The current study utilizes system dynamics to model the determinants of youth smoking and simulate effects of anti-smoking policies in the context of North Dakota, a state with one of the lowest cigarette tax rates in the USA.

Methods: An explanatory model was built to replicate historical trends in the youth smoking rate. Three different policies were simulated: 1) an increase in cigarette excise taxes; 2) increased funding for CDC-recommended comprehensive tobacco control programs; and 3) enforcement of increased retailer compliance with age restrictions on cigarette sales.

Steady states and stability in metabolic networks without regulation.

Metabolic networks are often extremely complex. Despite intensive efforts many details of these networks, e.g.