The crystal structure of a mononuclear Pr complex with cucurbit[6]uril.

A new mononuclear complex, penta-aqua-(cucurbit[6]uril-κ ,')(nitrato-κ ,')praseodymium(III) dinitrate 9.56-hydrate, [Pr(NO)(CB6)(HO)](NO)·9.56HO (), was obtained as outcome of the hydro-thermal reaction between the macrocyclic ligand cucurbit[6]uril (, CHNO) with a tenfold excess of Pr(NO)·6HO.

Ultrasonic-assisted unusual four-component synthesis of 7-azolylamino-4,5,6,7-tetrahydroazolo[1,5-]pyrimidines.

Four-component reactions of 3-amino-1,2,4-triazole or 5-amino-1-pyrazole-4-carbonitrile with aromatic aldehydes and pyruvic acid or its esters under ultrasonication were studied. Unusual for such a reaction type, a cascade of elementary stages led to the formation of 7-azolylaminotetrahydroazolo[1,5-]pyrimidines.

Preparation of thioamide building blocks via microwave-promoted three-component kindler reactions.

A microwave-enhanced variation of the Kindler thioamide synthesis is introduced. Taking advantage of the sealed vessel capabilities of a dedicated single-mode microwave reacto,r a diverse selection of 13 aldehyde and 12 amine precursors was utilized in the construction of a representative 34-member library of substituted thioamides. The three-component condensations of aldehydes, amines, and elemental sulfur were carried out using 1-methyl-2-pyrrolidone (NMP) as solvent employing microwave flash heating at 110-180 degrees C for 2-20 min.

Traceless solid-phase synthesis of bicyclic dihydropyrimidones using multidirectional cyclization cleavage.

Solid-phase and solution-phase protocols for the synthesis of furo[3,4-d]pyrimidines, pyrrolo[3,4-d]pyrimidines, and pyrimido[4,5-d]pyridazines are reported. The multistep solid-phase sequence involves the initial high-speed, microwave-promoted acetoacetylation of hydroxymethylpolystyrene resin with methyl 4-chloroacetoacetate. The immobilized 4-chloroacetoacetate precursor was subsequently subjected to three-component Biginelli-type condensations employing urea and a variety of aromatic aldehydes.