Publications by authors named "Oleksandr Herasun"
Objective: The aim: Analyzing literature sources, to assess possibilities of using the method of intradermal immunization with native autoleukocytes to treat different diseases, to investigate the areas of usage, efficacy and expediency of the technique in clinical practice.
Patients And Methods: Materials and methods: Analysis of literature sources associated with intradermal immunization with native autoleukocytes.
Conclusion: Conclusions: The possibilities of using the method of intradermal immunization with native autoleukocytes in the treatment of various diseases are consid¬ered in the literature review.
Objective: The aim: Was a trial of intradermal immunization with native autoleukocytes as a curative vaccine.
Patients And Methods: Materials and methods: Thus, 3-shot series vaccination by means of intradermal injection of autoleukocytes with 30 - 40 days interval was conducted for patients who, in spite of continuous (at least 2 years) therapy with nucleotide analogue, experienced HBV DNA reproduction. For this procedure, 80 - 100 ml of a patient's heparinized venous blood was being precipitated at the temperature 37оС for 120 - 140 minutes, after blood plasma was being centrifuged at 450g for 8 minutes.
Objective: Introduction: data about influence of intradermal vaccination with native autoleukocytes on activity level of pro-inflammatory cytokine tumor necrosis factor alpha in patients with chronic hepatitis B have been presented in the article. The aim: Based on positive results, obtained from autoleukocyte immunization in patients with psoriasis [14], the aim of our research was to use and study such therapy for reducing the synthesis of pro-inflammatory cytokine TNF-α in patients with chronic hepatitis B (chronic hepatitis B).
Patients And Methods: Materials and methods: Patients with chronic hepatitis B with high level of tumor necrosis factor alpha (≥30pg/ml) were vaccinated with native autoleukocytes (23); simultaneously, the same procedure was performed to patients (11) with low level of this cytokine (5pg/ml).
Intensification of antiviral therapy for chronic hepatitis B with autoleukocyte immunization.
Recent Pat Endocr Metab Immune Drug Discov
May 2018
Introduction: The article presents a new method of intensification of antiviral therapy for chronic hepatitis B with intradermal autoleukocyte immunization during treatment with a drug of nucleotide analogues - tenofovir (patent UA 113873 U, 2017); other curative vaccines for chronic hepatitis B are also regarded.
Objective: The research involves patients with chronic hepatitis B (30), whose replication of HBV DNA decreased to a certain level after long-lasting (over 2 years) antiviral therapy, its further reduction ceased. These patients underwent intradermal autoleukocyte immunization for intensification of antiviral therapy.
Introduction: Cold-shock precipitating proteins - cryoglobulins damage various vessels and, depending on the localization of damages, may lead to functional disorders of various organs and body systems. Evidently, cryoglobulinemia may have a negative influence on the reproductive system's condition, thus, this process requires detailed study.
Material And Methods: Clinical examples, indicating connection between cryoglobulinemia and spermatogenesis impairment are presented in the article.