Publications by authors named "Oleksander Frei"
Background: The corpus callosum (CC) is a brain structure with a high heritability and potential role in psychiatric disorders. However, the genetic architecture of the CC and the genetic link with psychiatric disorders remain largely unclear. We investigated the genetic architectures of the volume of the CC and its subregions and the genetic overlap with psychiatric disorders.
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- RICOPILI is an open-source Perl-based pipeline designed for efficient processing of large-scale multi-cohort genome-wide association studies (GWAS), focusing on quality control, imputation, and analysis.
- It features automated processes that enhance computational efficiency, including technical and genomic QC, association analysis, and polygenic risk scoring, setting it apart from other GWAS pipelines.
- The pipeline's adaptable architecture supports various high-performance computing environments and includes tutorials and simulated datasets for user training, available at its main website.
Migraine is a recurrent pain condition traditionally viewed as a neurovascular disorder, but little is known of its vascular basis. In epidemiological studies migraine is associated with an increased risk of cardiovascular disease, including coronary artery disease (CAD), suggesting shared pathogenic mechanisms. This study aimed to determine the genetic overlap between migraine and CAD, and to identify shared genetic risk loci, utilizing a conditional false discovery rate approach and data from two large-scale genome-wide association studies (GWAS) of CAD (C4D, 15,420 cases, 15,062 controls; CARDIoGRAM, 22,233 cases, 64,762 controls) and one of migraine (22,120 cases, 91,284 controls).
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