Publications by authors named "Oleg Rozanov"
Cancer Res Commun
August 2024
Article Synopsis
- Membrane-associated 70 kDa heat shock protein (mHsp70) plays a crucial role in the migration and invasion of malignant brain tumor cells, as observed in patient samples.
- Advanced techniques like inverted confocal microscopy and mass spectrometry showed that mHsp70 is prominently expressed on the surface of cancer cells, particularly in areas surrounding the tumors.
- Inhibiting HSP70 with small molecules significantly reduced cancer cell invasiveness and delayed tumor progression in animal models, suggesting that targeting mHsp70 could be a promising strategy for developing new cancer therapies.
