Publications by authors named "Oleg N Fokin"
Nucleic Acids Res
January 2003
Article Synopsis
- Analyzing gene regulatory networks is a complex challenge in postgenomic research, with a focus on transcription factor (TF) binding sites that can impact disease phenotypes.
- The rSNP_Guide system helps predict these TF binding sites and has been validated by established connections between TF sites and diseases, as well as experimental data.
- The tool identifies potential TF sites in similar genes based on known alterations, classifying their TF-DNA interactions as 'present', 'weak', or 'absent', with statistical significance for each classification.
Article Synopsis
- The human genome sequencing has spurred significant advancements in bioinformatics, particularly in analyzing single nucleotide polymorphisms (SNPs).
- rSNP_Guide is a developed tool that predicts transcription factor binding sites based on DNA sequence alterations, which may relate to diseases.
- The system has been validated using various genes linked to diseases and has shown effectiveness in analyzing important SNPs in both human and mouse genes.
