Publications by authors named "Ole Jonas Boeken"
Patient-Reported Outcome Measures in NMDA Receptor Encephalitis.
Neurol Neuroimmunol Neuroinflamm
January 2025
Background And Objectives: The characteristics of persistent long-term symptoms and their contribution to subjective quality of life remain unclear in patients with NMDAR encephalitis. In this study, we aimed to evaluate postacute neuropsychiatric symptoms, subjective cognitive complaints, and disease coping mechanisms and identify predictors of health-related quality of life (HRQoL) after N-methyl-D-aspartate receptor (NMDAR) encephalitis.
Methods: This cross-sectional observational study investigated patients with NMDAR encephalitis in the postacute phase.
Background: N-methyl-D-aspartate-receptor (NMDAR) encephalitis is a rare neurological autoimmune disease with severe neuropsychiatric symptoms during the acute phase. Despite good functional neurological recovery, most patients continue to experience cognitive, psychiatric, psychological, and social impairments years after the acute phase. However, the precise nature and evolving patterns over time of these long-term consequences remain unclear, and their implications for the well-being and quality of life of predominantly young patients have yet to be thoroughly examined.
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- - The ENIGMA Anxiety Working Group studied brain structural differences between individuals with specific phobias and healthy participants, focusing on subtypes of phobias like animal and blood-injection-injury (BII) while examining how these differences relate to symptom severity and age.
- - A total of 1,452 participants with phobias and 2,991 healthy subjects were analyzed, revealing that those with phobias exhibited smaller subcortical volumes and varying cortical thickness, especially noted in adults rather than youths.
- - The results indicate that brain alterations in specific phobias are more significant than in other anxiety disorders, revealing distinct neural underpinnings linked to fear processing across different phobia types, highlighting a
Introduction: The human intraparietal sulcus (IPS) covers large portions of the posterior cortical surface and has been implicated in a variety of cognitive functions. It is, however, unclear how cognitive functions dissociate between the IPS's heterogeneous subdivisions, particularly in perspective to their connectivity profile.
Methods: We applied a neuroinformatics driven system-level decoding on three cytoarchitectural distinct subdivisions (hIP1, hIP2, hIP3) per hemisphere, with the aim to disentangle the cognitive profile of the IPS in conjunction with functionally connected cortical regions.