6-Hydroxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline Demonstrates Neuroprotective Properties in Experimental Parkinson's Disease by Enhancing the Antioxidant System, Normalising Chaperone Activity and Suppressing Apoptosis.

Parkinson's disease (PD) is a neurodegenerative disease, whereby disturbances within the antioxidant defence system, increased aggregation of proteins, and activation of neuronal apoptosis all have a crucial role in the pathogenesis. In this context, exploring the neuroprotective capabilities of compounds that sustain the effectiveness of cellular defence systems in neurodegenerative disorders is worthwhile. During this study, we assessed how 6-hydroxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline (HTHQ), which has antioxidant properties, affects the functioning of the antioxidant system, the activity of NADPH-generating enzymes and chaperones, and the level of apoptotic processes in rats with rotenone-induced PD.

[Investigation of the possibility of obtaining butter with a high content of unsaturated fatty acids].

Polyunsaturated fatty acids (PUFA) consumed with dietary fats are physiologically active substances involved in metabolic processes in the organism, in particular, carbohydrate-fat and cholesterol metabolism, regulation of redox processes. Butter is one of the main food items of the daily human diet. The basis of butter is milk fat, which is characterized by a rich fatty acid composition and unique properties.

Indole-3-carbinol mitigates oxidative stress and inhibits inflammation in rat cerebral ischemia/reperfusion model.

Ischemia is a significant pathogenetic factor of stroke with very limited treatment options. The objective of our research was to evaluate the protective properties of indole-3-carbinol (I3C) and its effect on redox status parameters, inflammation, and apoptosis intensity in cerebral ischemia/reperfusion injury (CIRI) in rats. I3C administration to CIRI rats decreased levels of oxidative stress markers and improved aerobic metabolism compared to the animals with CIRI.

[Forensic chemical detection of furadan].

Isolation of furadan from biological material by ethyl acetate is considered. Column chromatography with silicone gel L 100/160micro was used to purify extractions from biological objects. A technique was elaborated for identification and quantitation of furadan in cadavers.

[Nosocomial respiratory infections in patients with bronchial asthma].

Aim: To study incidence and causes of nosocomial respiratory infection (NRI) and its influence on clinical manifestations of bronchial asthma (BA).

Material And Methods: 5212 inpatients of the pulmonary department were examined from 1994 to 2000.

Results: NRI was found in 41 of 912 patients with BA (4.

[The 1st results in the realization of the Harm Reduction program for intravenous narcotic users in the city of Penza].

To achieve the aims of the project, the following stages were consecutively defined: (1) the exchange of syringes, organized by outreach workers, with the simultaneous popularization of the project, (2) the orientation of intravenous drug users to attending syringe exchange stations and (3) the extension of the area covered by the activities of outreach workers. Our experience showed that outreach workers, especially those working in the street, were the main force to count on for achieving success in the work of the projects. The budget of the project should provide for the publication of information material.

[Stress in the etiology of radiation injury. Role of regulatory mechanisms].

Radiation damage as stress is regarded in the review. The place of lipid peroxidation in the starting of stress reaction and the possibility of the application of antioxidants and thymus preparations as factors which lower the hardness of radiation damage are considered.

[The system of psychoprophylactic measures and psychiatric care in the Strategic Missile Forces].

Since 1992 psychiatric morbidity, hospitalisation and discharge rates among the SRF personnel show a tendency to increase, reaching accordingly 7.7/1000, 7.3/1000 and 2.

[Pro-oxidant and antioxidant homeostasis in guinea pigs following fractionated x-ray irradiation at low doses and the correction of disorders with an antioxidant complex].

The state of pro-oxidant-antioxidant homeostasis in guinea pigs exposed to whole-body fractionated X irradiation (5 fractions of 0.2 Gy at a 24 hr interval, up to total dose of 1.0 Gy, at a dose rate of 0.

[An epidemiological analysis of postoperative suppurative pathology in surgical hospitals].

Approaches to the epidemiological analysis of postoperative wound complications in surgical hospitals are summarized. The indices for the evaluation of the epidemic situation in surgical departments (the ratio of severe and mild forms of complications, severe and posthospital complications) are proposed. To determine the site of infection, the method of graphic analysis, involving the fixation of dates of the operation and the appearance of the complication and taking into account regularities in the development of the outbreak, the depth and severity of the lesion, is proposed.

Care of the critically ill child after liver transplantation.

The many potential problems related to liver transplantation are intensified when the recipient is an infant or a child. The nursing diagnoses and interventions presented in this article can be a guide to the critical care nurse in management of sources of infection, rejection by the patient's own immune system, fluid volume, and electrolyte balance.

[The bases of epidemiological surveillance for postinjection complications].

To carry out the epidemiological analysis of postinjection suppurations and to introduce the relevant prophylactic measures, the forms of registration and account for suppurative inflammatory diseases should be legitimized and the data on such cases per the number of injections made at therapeutic and prophylactic institutions and their branches should be calculated. The organization of centralized sterilization of instruments and the 100% provision of all institutions with these instruments can reduce the occurrence of postinjection suppurations.

[Various problems of epidemiology and prevention of suppurative-inflammatory complications in surgery].

An epidemiological analysis of pyo-inflammatory diseases (PID) in surgical department of multiprofile hospitals has been made. PIDs were diagnozed in 16.2% of patients operated upon.

[Mechanism of initiation of intracellular ice formation].

Intracellular ice crystallization was studied by the method of cryomicroscopy in the systems modeling a biological suspension, such as erythrocyte concentrates. Initiation of crystallization by extracellular ice through hydrophilic channels has been shown to be the most probable mechanism of intracellular ice formation.