Potential of Interferon Lambda as an Inhibitor of SARS-CoV-2.

This study provides an overview of scientific results on the feasibility of using type III interferons against SARS-CoV-2. We have analyzed data obtained from the PubMed electronic database for the period 2020‒2022. The results of our own studies of pharmacological substances based on recombinant IFN-λ1 and its pegylated form are also presented.

[Potential of Interferon Lambda as an Inhibitor of SARS-CoV-2].

This study provides an overview of scientific results on the feasibility of using type III interferons against SARS-CoV-2. We have analyzed data obtained from the PubMed electronic database for the period 2020-2022. The results of our own studies of pharmacological substances based on recombinant IFN-λ1 and its pegylated form are also presented.

Pharmacokinetic Parameters of Oral Pegylated IFN-λ1.

We studied the pharmacokinetics of a pegylated IFN-λ1 (PEG IFN-λ1) after its oral administration to rats in different therapeutic doses. The hypothesis on linear pharmacokinetics of PEG IFN-λ1 within the dose range of 2.6-7.

Evaluation of the Anti-Viral Activity of Human Recombinant Interferon Lambda-1 against SARS-CoV-2.

The antiviral activity of recombinant human IFN-lambda type 1 (IFNλ-1) against culture strain of SARS-CoV-2 virus was determined by infecting a highly sensitive VeroE6 coronavirus cell culture after preincubation test (the cell monolayer was incubated with 4-fold dilutions of IFNλ-1 in a concentration range of 0.16-42,500 ng/ml in a culture medium for 12 h at 37°C) and without preincubation (simultaneous addition of different concentrations of IFNλ-1 and SARS-CoV-2 infection in a dose of 102 TCID50). The created recombinant human IFNλ-1 demonstrated obvious antiviral activity against SARS-CoV-2 virus in vitro.

[The criterion of lactation stability in cows].

The stability of the lactation curves of high-productive cows (4000-9000 kg of milk per lactation period) was investigated. A new criterion of assessment of the lactation stability was proposed. Basic genetic criteria of the index of lactation stability (coefficients inheritance and reiteration) were responded.

[The development and introduction of diagnostic and treatment methods for neurovascular diseases of the upper extremity].

The diagnosis complex, permitting to reveal the disease cause and the character of the affect faulty and quickly, was elaborated, based on the experience of treatment analysis of more than 600 patients with the upper extremities neurovascular diseases--thoracic inlet syndrome, Raynaud disease and syndrome. Methods of conservative therapy are introduced, indications for operative treatment are substantiated. Application of new methods of restoration-reconstructive interventions permitted to raise the treatment quality, particularly in seriously ill patients with complicated forms of upper extremities neurovascular diseases.

[Surgical treatment of multistage occlusion of the abdominal aorta and iliac and femoral arteries].

The results of surgical treatment of 26 patients with "multistage" occlusion, who underwent reconstructive operation on two segments (group 1), and 29 patients, who underwent ultrasound disobliteration of the femoral arteries together with the reconstructive operation (group 2), are presented. In group 1, a good immediate result was noted in 80.8%, a good long-term result--in 61.

[Late results of stereotaxic surgery in parkinsonism].

The authors analyzed the long-term results of uni- and bilateral stereotaxic operations in 70 patients (38 males and 32 females) with idiopathic and postencephalitic parkinsonism aged 32 to 68 years at the time of examination. It was established that the effect of the first operation with regard to tremor and muscular rigidity did not depend on the side of surgical intervention. Noticeable difference was observed between the results of the first and the second operation in relation to their efficacy and sequel incidence.

[Diagnosis and surgical treatment results in neurovascular thoracic outlet compression syndrome].

A detailed study of 44 patients with the neuro-vascular compression syndrome of thoracic exit has established the diagnostic value of clinical and special methods of diagnosing the disease. The most frequent symptoms were pain in the anterior scalene muscle (ASM) during palpation (96%) and paresthesia in fingers (93%). Rheography, arteriography and phlebography of the upper extremities combined with the positional tests should be resorted to.

[Features of catecholamine metabolism in the families of patients with idiopathic parkinsonism].

From clinico-genealogic-biochemical examination of 10 families of probands suffering from idiopathic parkinsonism (clinical, electromyographic and tremographic studies, determination of the content of adrenaline and norepinephrine in blood and of the excretion with urine of DOPA, dophamine, norepinephrine and adrenaline) it is concluded that the hereditary factors play an important role in the genesis of idiopathic parkinsonism. A number of medico-genetical recommendations are proposed.