Five new flavonoids and their pharmacological activities from Iris tenuifolia Pall.

Five new components including two new isoflavones, 5, 7, 2', 3'-tetrahydroxy-6-methoxyisoflavone (1), 5, 7, 2', 3'-tetrahydroxy-8-methoxyisoflavone (2), one flavonol 3, 5, 3', 4'-tetrahydroxy-7, 2'-dimethoxyflavonol (3), one flavanone (2S)-5, 7, 3'-trihydroxy-2'-methoxyflavanone (4), and one flavanonol (2R, 3R)-3, 5, 3', 4'-tetrahydroxy-7, 2'-dimethoxyflavanonol (5), along with nine known flavonoids (6-14) were isolated from under ground parts of Iris tenuifolia Pall. Their structures were elucidated by NMR and HRESIMS data and by comparison of CD spectra with compounds having similar structure. The separated compounds were evaluated for in vitro antioxidant activities by DPPH and ABTS.

Chromane Derivatives from Underground Parts of and Their In Vitro Antimicrobial, Cytotoxicity and Antiproliferative Evaluation.

Phytochemical investigation of the ethanol extract of underground parts of Pall. afforded five new compounds; an unusual macrolide termed moniristenulide (), 5-methoxy-6,7-methylenedioxy-4--2'-cycloflavan (), 5,7,2',3'-tetrahydroxyflavanone (), 5-hydroxy-6,7-dimethoxyisoflavone-2'---d-glucopyranoside (), 5,2',3'-dihydroxy-6,7-dimethoxyisoflavone (), along with seven known compounds (-, -). The structures of all purified compounds were established by analysis of 1D and 2D NMR spectroscopy and HR-ESI-MS.