Curcumin improves the ability of donepezil to ameliorate memory impairment in : involvement of cholinergic and cnc/Nrf2-redox systems.

One of the well-established models for examining neurodegeneration and neurotoxicity is the model of aluminum-induced toxicity. Anti-cholinesterase drugs have been combined with other neuroprotective agents to improve Alzheimer's disease management, but there is not much information on the combination of anti-cholinesterases with dietary polyphenols to combat memory impairment. Here, we assess how curcumin influences some of the critical therapeutic effects of donepezil (a cholinesterase inhibitor) in AlCl-treated .

Evaluating Water bitter leaf () and Scent Leaf ( extracts as sources of nutraceuticals against manganese-induced toxicity in fruit fly model.

Tropical vegetables remain one of the major sources of functional foods and nutraceuticals, while their constituent phytochemicals, especially alkaloids, have been reported to exhibit neuroprotective properties. Here, the protective effect of alkaloid extracts from Scent leaf () and Water bitter leaf () on manganese (Mn)- induced toxicity in wild type fruit fly () model was investigated. Flies were exposed to 30mM of Mn, the alkaloid extracts (20 and 200µg/g) and co-treatment of Mn plus extracts, respectively.