Anti-nociceptive Effect of Euphorbia hirta Leaf Extract: Involvement of Adenosine, Cholinergic, and Opioid Receptors.

Objective: The study was designed to investigate the anti-nociceptive activity of Euphorbia hirta leaf and its possible mechanism of action.

Methods: The extract of Euphorbia hirta obtained from the leaf was prepared as per standard procedures and evaluated at the three doses (300, 600, and 1200 mg/kg, i.p).