Publications by authors named "Olawale O Obembe"
African walnut (Tetracarpidium conophorum) extract upregulates glucocerebrosidase activity and circumvents Parkinsonian changes in the Hippocampus via the activation of heatshock proteins.
J Chem Neuroanat
July 2023
Background: Neurodegenerative illnesses like Parkinson's and Alzheimer's are largely caused by the accumulation of aggregated proteins. Heat shock proteins (HSPs), which are molecular chaperons, have been linked with the modulation of β-glucocerebrosidase (GCase) function encoded by GBA1 and Synucleinopathies. Herein, the chaperonic properties of African walnut ethanolic extract (WNE) in manganese-induced Parkinsonian neuropathology in the hippocampus was examined.
View Article and Find Full Text PDFHepatoprotective effects of stem bark against cadmium-induced toxicity in male Wistar rats.
J Basic Clin Physiol Pharmacol
February 2021
Article Synopsis
- The study investigates how a certain extract can protect against liver damage caused by cadmium (Cd) in rats, focusing on effects on liver health and lipid levels.
- Cadmium exposure led to increased total cholesterol and LDL, and decreased HDL, along with oxidative stress markers in the liver, indicating liver damage.
- Treatment with the extract countered these harmful effects by maintaining healthy lipid profiles and reducing oxidative stress in the liver tissues.
Article Synopsis
- The study investigates the male reproductive toxicity of Moringa oleifera seed extracts, specifically focusing on methanol and hexane fractions.
- Male rats were treated with these fractions for six weeks, with the methanol fraction showing a significant reduction in testosterone, sperm motility, and count, while the hexane fraction showed no adverse effects.
- Both fractions increased antioxidant levels, but the methanol fraction was linked to reproductive toxicity, suggesting a complex interaction between these extracts and male reproductive health.
Effects of aqueous extract of seed on cadmium-induced reproductive toxicity in male Wistar rats.
Afr Health Sci
September 2018
Background: seeds have been reported to increase sexual activity of male rats but its mechanism of action remains unknown.
Objective: Cadmium is a heavy metal that induces reproductive toxicity. To elucidate its possible mechanisms of action, the effects of aqueous extract of Moringa seeds (AEMS) on Cadmium-induced reproductive damage were investigated.