Publications by authors named "Olavo Speranza de Arruda"
Is the production of reactive oxygen and nitrogen species by macrophages associated with better infectious control in female mice with experimentally disseminated and pulmonary mucormycosis?
Amanda Ribeiro Dos Santos Thais Fernanda Fraga-Silva Débora de Fátima Almeida-Donanzam Angela Carolina Finatto Camila Marchetti Olavo Speranza de Arruda Maria Sueli Parreira de Arruda
PLoS One
December 2022
Article Synopsis
- * BALB/c mice macrophages (PMΦ) produced more hydrogen peroxide (H2O2) and inflammatory factors than Swiss mice, indicating a stronger immune response against the fungus.
- * Overall, the study highlights that PMΦ is a more effective immune responder against R. oryzae than alveolar macrophages (AMΦ), especially in BALB/c mice, which correlates with better fungal clearance.
IFN-γ Mediated Signaling Improves Fungal Clearance in Experimental Pulmonary Mucormycosis.
Amanda Ribeiro Dos Santos Thais Fernanda Fraga-Silva Débora de Fátima Almeida-Donanzam Rodolfo Ferreira Dos Santos Angela Carolina Finato Olavo Speranza de Arruda Maria Sueli Parreira de Arruda
Mycopathologia
February 2022
We established three immunocompetent murine models of pulmonary mucormycosis to determine the involvement of the adaptive immune response in host resistance in pulmonary mucormycosis, a rapidly fatal disease caused mainly by Rhizopus spp. Immunocompetent inbred (C57BL/6, BALB/c) and outbred (Swiss) strains of mice were inoculated with R. oryzae via the intratracheal route.
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