Publications by authors named "Olatz Izaola-Jauregui"
Background and aims: omentin-1 might present a potential role in metabolic syndrome (MS). The aim of our investigation was to evaluate the relationship between omentin-1 and nascent MS. Methods: we carried out a cross-sectional study in 606 obese subjects.
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- User-friendly assessment tools for malnutrition are essential, and this study focused on a personalized nutrition intervention using a new oral nutritional supplement and AI technology to track outcomes in malnourished patients.
- The study included 65 patients and showed significant improvements over three months, with weight loss decreasing, and a drop in the prevalence of malnutrition and severe malnutrition.
- Additionally, older patients experienced gains in muscle thickness, strength, and function, indicating that tailored interventions can effectively enhance nutrition and combat malnutrition in patients with disease-related issues.
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- The weight-adjusted waist index (WWI) was evaluated for its ability to predict metabolic syndrome (MS) specifically among Caucasian individuals with obesity.
- A study involving 2,162 obese Caucasian patients found that those in the highest WWI category were significantly more likely to have MS, with adjusted odds ratios demonstrating a clear trend linked to higher WWI levels.
- Results indicated that the WWI has good predictive accuracy for MS with a cut-off value of 11.59, showing a sensitivity of 70% and specificity of 93.4%.
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- ALS is a progressive neurodegenerative disease associated with high rates of malnutrition, which can affect patient outcomes; this study aims to evaluate the effectiveness of muscle ultrasonography in identifying malnutrition and predicting prognosis in ALS patients.
- The study analyzed 37 ALS patients using various methods to assess nutritional status, including anthropometric measurements and electrical bioimpedance analysis, alongside muscle ultrasonography of the quadriceps to evaluate both muscle mass and quality.
- Results found that nearly 46% of patients were malnourished according to established criteria, with significant correlations between muscle mass measured by ultrasound and various markers of body composition, indicating the potential usefulness of muscle ultrasonography in ALS management.
Adherence and impact of an oral nutritional supplement enriched in leucine, EVOO, EPA and DHA, and beta-glucans on the coverage of energy and protein requirements in patients with cancer and malnutrition: Alisenoc study.
Nutrition
April 2024
Objective: The aim of this study was to evaluate the impact of an enhanced ONS (enriched in EPA, DHA, leucine, and beta-glucans) on the dietary intake of cancer patients.
Methods: A randomized, double-blind, parallel, controlled, and multicenter clinical trial was conducted in patients with cancer and malnutrition. The trial compared prescribed dietary advice and two packs per day, for 8 weeks, of a hypercaloric (400 kcal/pack) and hyperproteic ONS (20 g/pack) with fiber and specific ingredients (leucine, EPA and DHA, and beta-glucans) (enhanced-ONS) versus an isocaloric and isoproteic formula (standard-ONS) without specific ingredients.
Background: Progression diets after bariatric surgery (BS) are restricted in calories and protein, and they may induce a worsening of body composition. The aim of this study was to evaluate the effect of a modified diet with an oral nutritional supplement that is hyperproteic and normocaloric over the body composition.
Methods: A two-arm ambispective observational cohort study was designed.
: The present study was designed to investigate SNP rs17300539 in the gene and its relationships with obesity, metabolic syndrome (MS), and serum circulating adiponectin. : The present design involved a Caucasian population of 329 subjects with obesity. Anthropometric and adiposity parameters, blood pressure, biochemical parameters, and the percentage of patients with metabolic syndrome were recorded.
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- The SNP (rs3138167) is linked to metabolic disorders in obese individuals, and its impact on metabolic response post-diet intervention was unknown.
- In a study of 1,008 obese Caucasians, those carrying the T allele showed higher levels of insulin and other markers compared to non-T allele carriers both before and after a 12-week hypocaloric Mediterranean diet.
- Non-T allele carriers experienced significant improvements in metabolic markers like insulin and triglycerides, suggesting they had a better response to the dietary intervention than T allele carriers.
Unlabelled: Nutritional ultrasonography is an emerging technique for measuring muscle mass and quality. The study aimed to evaluate the relationship between the parameters of body mass and quality of ultrasonography with other parameters of morphofunctional assessment in patients with disease-related malnutrition (DRM).
Methods: A cross-sectional study was developed on 144 patients diagnosed with DRM according to the Global Leadership Initiative on Malnutrition (GLIM) criteria.
Introduction: The prevalence of malnutrition in patients with diabetes mellitus is high. In these patients, monitoring nutritional intervention is complex. Aims: To evaluate the evolution in the nutritional status in patients with diabetes/prediabetes and malnutrition with a diabetes-specific enteral formula.
View Article and Find Full Text PDFIntroduction: hyponatremia is the most frequent disturbance in hospitalized patients. This situation may influence the therapeutic approach in patients with total enteral tube feeding (TEN). Objective: to study the prevalence of hyponatremia and the clinical factors that are associated with increased risk in a population with TEN.
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- The study investigates the relationship between obesity and bone health in postmenopausal women, questioning the previously held belief that obesity protects against osteoporosis.
- It compares bone turnover markers and fracture risk over five years between women with obesity (BMI > 30) and those without (BMI < 30), including 250 participants.
- Results indicated that obese women had lower vitamin D and bone formation markers, along with higher parathyroid hormone levels, but no significant difference in fracture risk was found based on BMI.
Background: Muscular ultrasonography is a technique that allows assessing the amount and quality of muscle in a specific body region. The aim of the study was to compare the value of muscle ultrasonography in diagnosis of malnutrition with techniques such as anthropometry, handgrip strength and impedanciometry in patients with oncological pathology. Methods: Cross-sectional study in 43 patients with oncological pathology and high nutritional risk.
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- The CDKAL1 gene influences insulin secretion and glucose regulation, specifically through the rs7756992 genetic variant.
- A study involving 44 obese individuals following a partial meal replacement diet revealed notable effects on fasting glucose and insulin resistance based on genetic variations.
- Non-G allele carriers experienced significant improvements in fasting glucose, insulin levels, and HOMA-IR compared to G allele carriers after the diet, indicating a link between the genetic variant and glycemic response.
Background: The CDKAL1 (CDK5 Regulatory Subunit Associated Protein 1 Like 1) gene encodes cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated proten1 like 1. This protein has been shown to contribute to the glucose-dependent regulation of insulin secretion in pancreatic islets.
Aims: The aim of our study was to analyze the effects of the rs7756992 genetic variant of CDKAL1 gene on fasting glucose and insulin resistance after weight loss secondary to partial meal replacement hypocaloric diet (pMRHD).
Objective: the rs10830963 SNP of the MTNR1B gene may be related with biochemical changes after weight loss induced by caloric restriction. We investigated the role of this SNP on biochemical parameters after biliopancreatic diversion (BPD) surgery in morbid obese subjects. Patients and methods: one hundred and fifty-four patients with morbid obesity, without diabetes mellitus type 2, were enrolled.
View Article and Find Full Text PDFAims:to analyze the effects of the rs2419621 genetic variant of the ACSL5 gene on weight change and metabolic parameters after a partial meal-replacement hypocaloric diet. Methods: this was a non-randomized, single-treatment study with a formula-diet in 44 obese subjects with body mass index (BMI) greater than 35 kg/m2. Patients received nutritional education and a modified diet with two intakes of a normocaloric hyperproteic formula during 3 months.
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- The study investigates how the genetic variant rs16147 affects metabolic response and weight change in obese subjects following two different hypocaloric diets.
- Both diets led to improvements in adiposity, blood pressure, and leptin levels, but those with the A allele of rs16147 showed more significant decreases in insulin levels and insulin resistance (HOMA-IR) on the Mediterranean diet compared to the standard diet.
- The findings suggest that individuals carrying the A allele of rs16147 experience better metabolic outcomes from a hypocaloric Mediterranean diet than from a standard hypocaloric diet.
Article Synopsis
- The study compared the effects of replacing one versus two meals with nutritional supplements on body composition and cardiovascular risks in obese patients.
- A randomized clinical trial involving 112 participants assessed changes over three months, measuring weight loss, fat mass, and metabolic parameters.
- Both meal replacement strategies resulted in significant weight loss and improvements in health markers like blood pressure and cholesterol, with no notable differences between the one or two meal replacements.
Background and objectives: genetic variants of the APOA1 gene have been related to lipid profile in obese subjects. Our aim was to analyze the effects of the rs670 APOA1 gene polymorphism on metabolic changes secondary to an enriched-polyunsaturated fat vs. an enriched-monounsaturated fat hypocaloric diet.
View Article and Find Full Text PDFBackground: The choice of hypocaloric diets in obesity can affect bone health.
Aims: The aim of this study is to assess the effect of a hypocaloric diet in postmenopausal obese women and to determine the influence of weight reduction on bone metabolism.
Methods: This was a non-randomised, single-treatment study in 96 postmenopausal women with a body mass index (BMI) greater than 35kg/m and osteoarthritis.
Introduction: disease-related malnutrition (DRM) is currently a major challenge in our hospitals, both because of its high prevalence and because of the clinical and economic impact. Our study aims to assess the feasibility and importance of establishing a nutritional screening strategy in our Health Care System.
Patients And Methods: this is a prospective study carried out in a Surgery Ward.
Background: Knee osteoarthritis is a disease with a high prevalence in our environment, especially in women. Weight loss can improve the quality of life of these patients before surgery.
Objectives: To evaluate the effect of a meal-replacement diet on weight loss, body composition, and the improvement of the quality of life in obese women with knee osteoarthritis pending surgery.
Objective: The effects of normocalcemic hyperparathyroidism (NHPT) on bone remain unclear. The objective of this study was to evaluate differences in the trabecular bone score (TBS) of NHPT patients and asymptomatic hypercalcemic hyperparathyroidism (HHPT) patients.
Methods: We performed a prospective study that enrolled consecutive patients with asymptomatic hyperparathyroidism (NHPT and HHPT) with a follow-up ≥1 year at the University Hospital of Valladolid, Spain.