Publications by authors named "Olasiende Olusanya"
Article Synopsis
- The study explored how quercetin protects against immune suppression caused by cyclophosphamide (CYP) in male Wister rats, focusing on oxidative and inflammatory stress impacts.
- Quercetin, when administered alongside CYP, helped reduce oxidative stress and inflammation in brain regions by boosting antioxidant enzyme activity and lowering harmful markers like interleukin-6 and interferon-γ.
- Behavioral tests showed that quercetin significantly improved depressive-like behaviors in rats treated with CYP, suggesting its potential as a protective agent against stress-induced mental health issues.
The hepatic-renal toxicity associated with cyclophosphamide (CYP) treatment in both animals and humans have been reported. Quercetin, a dietary flavonoid, is known to elicit beneficial health effects. However, the influence of quercetin on the hepatic-renal toxicity associated with CYP-instigated indoleamine 2,3-dioxygenase is unavailable in the literature.
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