Attenuation of Experimental Cholesterol Gallstone Formation by Manganese Chloride in Mice: Role of NF-κβ Pathways.

Manganese (Mn), a trace element, has been documented to exert an important role in the metabolism of cholesterol. Cholesterol gallstone (CG) pathogenesis is directly linked to biliary cholesterol imbalance which could be due to diabetes complications or mismanagement. NF-κβ pathway, an inflammatory regulator, has been implicated in metabolic disease especially in the context of diabetes and gallstone formation.

Unveiling the complementariness of robotic tablet dispensing machines for elderly care: A bibliometric data analysis.

This study conducts a bibliometric analysis of academic papers and conference proceedings related to tablet dispensers, medicine dispensers, and pill dispensers within the framework of Sustainable Development Goal 03: Good Health and Well-Being. The analysis spans literature published between 1997 and 2023. Utilizing the Web of Science database, the study employs keywords such as "tablet dispenser," "medicine dispenser," and "pill dispenser" to gather relevant English-language papers classified as Proceeding Papers or Articles.

Kolaviron: a Bioflavonoid from Seed Extract of Garcinia kola Attenuates Chromium (VI)-Induced Gut Dysfunction and Oxidative Damage in Drosophila melanogaster.

Hexavalent chromium [Cr(VI)] is of public health significance due to its toxicity and carcinogenic effects. Kolaviron, a bio-flavonoid fraction from Garcinia kola seed, has been reported to possess gastroprotective and antioxidative properties. We hypothesize that Kolaviron-fortified diet will attenuate chromium (VI)-induced gut dysfunction and oxidative damage in Drosophila melanogaster.

Low-dose Potassium bromate enhances ischemia-reperfusion-induced gastric ulcer healing in Thyroidectomised Rats.

Gastric ulcer healing is impaired in both hypothyroid and hyperthyroid conditions.  Thyroid hormones regulate growth, energy metabolism and mitochondrial oxidative metabolism. Xenobiotics have been documented to negatively impact the thyroid gland at high doses but the redox and cellular interactions at low doses during wound healing process remains unclear.

Cement Dust Exposure Alters Secretory Functions, Biochemical Profile and Morphology of Gastrointestinal Tissues in Rats Exposed to Cement Dust.

Asides direct gastrointestinal exposure, inhalation route is another major xenobiotic exposure pathway to the gastrointestinal tract via mucociliary escalator. This triphasic study assesses cement dust inhalatory exposure effect on the possible alterations of the gastrointestinal tissues and secretion. 72 male, sixteen (16) weeks old Wistar rats were randomized into 3 different phases of 24 animals.

Bibliometric structured review of tuberculosis in Nigeria.

The tuberculosis burden is growing in Nigeria along with its population. For example, Nigeria has the sixth highest TB burden globally, with an estimated 4.3 per cent multi-drug resistance in new cases.

A bibliometric review of global visibility, impact and adoption of electronic invoicing: The past and the future.

The objective of this study is to conduct a bibliometric review of literature on electronic invoicing to provide an understanding of the growing field and valuable sources for future research. A total of 191 papers within the period of 1997 to July 2021 were included in our analysis. The systemic analysis revealed several insights in research progression over two decades, relevant authors and leading institutions including countries, most frequent keywords, and the principal methodologies and theories adopted.

Bibliometric analysis of contributions to COVID-19 research in Malaysia.

Introduction: The advent of COVID-19 has led to an exponential rise in related publications to provide a knowledge driven approach to tame the tide of infection and impact in all spheres. This study gives an insight into COVID-19 research publication pattern in Malaysia using bibliometric analysis.

Method: COVID-19 publications on Scopus database between January 1, 2020, and August 26, 2022, were extracted using predetermined search strings.

Naringenin modulates Cobalt activities on gut motility through mechanosensors and serotonin signalling.

Cobalt chloride-(CoCl) exerts beneficial and toxic activities depending on dose however Naringenin-(Nar) a flavonoid, chelates heavy metals. Absorption of ingested heavy metals, or chelates are dependent on gut motility (gastric emptying and intestinal transit time) and mechanosensor regulation. Literature is vague on CoCl activities on gut motility and mechanosensor nor probable chelating actions with naringenin which was investigated in this study.

Strength Characteristics of Electrospun Coconut Fibre Reinforced Polylactic Acid: Experimental and Representative Volume Element (RVE) Prediction.

Environmental conservation and waste control have informed and encouraged the use of biodegradable polymeric materials over synthetic non-biodegradable materials. It has been recognized that nano-sized biodegradable materials possess relatively good properties as compared to conventional micron-sized materials. However, the strength characteristics of these materials are inferior to fossil-based non-biodegradable materials.

Short-term acute constipation and not short-term acute diarrhea altered cardiovascular variables in male Wistar rats.

Gastrointestinal dysmotility is a substantial public health challenge globally. Based on previous findings in developed countries, it has been observed that there is an association between diarrhea, constipation, and some cardiovascular variables. This study investigated the effects of experimentally-induced short-term acute constipation and short-term acute diarrhea on certain cardiovascular variables in rats.

Standardized experimental model for cement dust exposure; tissue heavy metal bioaccumulation and pulmonary pathological changes in rats.

A controlled experimental model of exposure to aerosols particularly for cement dust was recently invented in a study from the laboratory that found high serum levels of heavy metals, decrease gastrointestinal motility, and altered hematological variables in cement dust exposed rats. However, reproducibility was not considered. This work aims at standardizing the model and investigating preliminary toxicological indicators.

Dose-dependent changes in Haematological and Serum Biochemical Variables in Rats Exposed to Sodium Metavandate in Male Wistar Rats.

The interest in the role of vanadium compounds in living organisms has grown tremendously especially since the report of its glycemic normalization activity in the 1980s. There has been reports of both its toxic as well as positive effects, thus there is a paucity of information on the essentiality of this element in biological systems. In this study, the effect of different doses of sodium metavanadate on the haematological and biochemical variables of male Wistar rats was investigated.

Potassium bromate (KBrO) modulates oxidative stress and inflammatory biomarkers in sodium hydroxide (NaOH) - induced Crohn's colitis in Wistar rats.

Potassium bromate (KBrO) present in consumed ozonised water was recently documented to exacerbate experimental gastric ulcer. Information, however, is vague as regards its effects in the colon where water reabsorption occurs. In this study, we observed the possible effects of KBrO on oxidative stress and inflammatory biomarkers in sodium hydroxide (NaOH) - induced Crohn's colitis (CC).

Biochemical and histopathological effects of low dose vanadium in the healing of acetic acid-induced colitis in male wistar rats.

Objectives: Vanadium has been reported to possess relevant therapeutic properties such as anti-diabetic and anti-tumoral. This study aimed at determining the effects of vanadium on experimentally induced colitis in rats.

Methods: Forty-five male Wistar rats (103 ± 3.

Exposure to Mosquito Coil Smoke Delays Healing of Acetic Acid Induced Gastric Ulcer in Male Wistar Rats.

Mosquito coil fumes (MCF) is used in several Nigerian homes and some part of the world with reported grave consequences to the respiratory tract majorly. There is paucity of information on its outcome on the gastrointestinal tract being a related organ to the respiratory tract. Forty five male Wistar rats (123.

An Editor bows out - Tribute to former Editor, Prof. Anthony Ebeigbe as he retires.

This tribute was written to appreciate the longest-serving Editor-in-Chief in the history of this journal as he retires from active teaching and research. His contributions to the Physiological Society of Nigeria is outstanding and his relationship with colleagues highly commendable.

Potassium bromate cytotoxicity in the Wister rat model of chronic gastric ulcers: Possible reversal by protocatechuic acid.

The interaction between ingested xenobiotics and the gastrointestinal epithelium influences the possibility of gut epithelial cytotoxicity and systemic toxicity. Potassium bromate (KBrO ) has been shown to perturb the central nervous system and it may be carcinogenic, albeit it is used as a food additive. This highlights the need to understand KBrO 's effect on the stomach epithelium.

Generalized cure rate model for infectious diseases with possible co-infections.

This research mainly aims to develop a generalized cure rate model, estimate the proportion of cured patients and their survival rate, and identify the risk factors associated with infectious diseases. The generalized cure rate model is based on bounded cumulative hazard function, which is a non-mixture model, and is developed using a two-parameter Weibull distribution as the baseline distribution, to estimate the cure rate using maximum likelihood method and real data with R and STATA software. The results showed that the cure rate of tuberculosis (TB) patients was 26.

Attenuation of ischemia-reperfusion-induced gastric ulcer by low-dose vanadium in male Wistar rats.

Aim: Vanadium, a trace element found in food and water sources has been previous reported to attenuate ulcer formation without much insight into its mechanism of action. This study highlights the mechanism by which vanadium exhibits its gastro-protective activity.

Main Methods: Eighty male Wistar rats (80-100 g) were randomized into 8 equal groups.

Immunohistochemical Studies of Age-Related Changes in Cell Proliferation and Angiogenesis during the Healing of Acetic Acid-Induced Gastric Ulcers in Rats.

Cell proliferation and angiogenesis are of utmost importance for healing to take place. The KI67 and EGFR proteins are markers of cell proliferation, while CD31 and factor VIII are markers of angiogenesis. To elucidate the mechanism responsible for delayed healing of the gastric injury in old age, we analyzed the expression of these markers in rats of different months during the healing of an acetic acid-induced gastric ulcer.