Publications by authors named "Olajumoke Tolulope Idowu"
Article Synopsis
- There is currently no cure for diabetes, particularly type 2 diabetes mellitus (T2DM), but various pharmaceutical therapies are available for its management, categorized by their mechanisms of action.
- While some medications show effectiveness, they come with significant side effects from prolonged use.
- Phytochemicals found in medicinal plants are emerging as promising candidates for new treatments, as they can activate the glucagon-like peptide-1 receptor (GLP-1R) similarly to existing agonists, potentially offering a more affordable and safer alternative for T2DM management.
Comparison of Bioactive Compounds Characterized from with an FDA-Approved Drug against Schistosomal Agents: New Insight into Schistosomiasis Treatment.
Molecules
April 2024
The burden of human schistosomiasis, a known but neglected tropical disease in Sub-Saharan Africa, has been worrisome in recent years. It is becoming increasingly difficult to tackle schistosomiasis with praziquantel, a drug known to be effective against all , due to reports of reduced efficacy and resistance. Therefore, this study seeks to investigate the antischistosomal potential of phytochemicals from against proteins that have been implicated as druggable targets for the treatment of schistosomiasis using computational techniques.
View Article and Find Full Text PDFInsight into antioxidant-like activity and computational exploration of identified bioactive compounds in Talinum triangulare (Jacq.) aqueous extract as potential cholinesterase inhibitors.
BMC Complement Med Ther
March 2024
Background: Recent reports have highlighted the significance of plant bioactive components in drug development targeting neurodegenerative disorders such as Alzheimer's disease (AD). Thus, the current study assessed antioxidant activity and enzyme inhibitory activity of the aqueous extract of Talinum triangulare leave (AETt) as well as molecular docking/simulation of the identified phytonutrients against human cholinesterase activities.
Methods: In vitro assays were carried out to assess the 2,2- azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS) cation radicals and cholinesterase inhibitory activities of AETt using standard protocols.
GC-MS analysis of aqueous extract of and ameliorative potential of its biosynthesized gold nanoparticles against cadmium-induced kidney damage in rats.
Heliyon
June 2023
Plants possess compounds serving as reducing agents for green synthesis of gold nanoparticles (AuNPs), which is currently considered for biomedical application. Exposure to cadmium (Cd) can affect the functional integrity of the several organs such as kidney and liver. (NL) is known for its several medicinal properties, including its protective role against tissue damages.
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