Mesoporous Oxidized Mn-Ca Nanoparticles as Potential Antimicrobial Agents for Wound Healing.

Managing chronic non-healing wounds presents a significant clinical challenge due to their frequent bacterial infections. Mesoporous silica-based materials possess robust wound-healing capabilities attributed to their renowned antimicrobial properties. The current study details the advancement of mesoporous silicon-loaded MnO and CaO molecules (HMn-Ca) against bacterial infections and chronic non-healing wounds.

Four New Unusual Pentacyclic Triterpenoids from the Roots of (L.) Ait.

Four new unusual pentacyclic triterpenoids (-) were isolated from the roots of (L.) Ait. Their structures were elucidated by 1D and 2D NMR analysis, single-crystal X-ray diffraction and HRESIMS.

Chemical Constituents from the Roots of (L.) Ait. and their Cytotoxicity to the Cancer Cell Lines.

Background: The roots of is the Traditional Chinese Medicine (TCM) with analgesic and anesthetic effects. However, relatively fewer studies on the chemical compositions and the biological activities of the roots of have been carried out till now. We studied the chemical compositions of the roots of planted in Fujian Province to discover new compounds from this TCM to develop new drugs or drug candidates.

Isolation, Structural Elucidation of a New Triterpenoid from the Roots of (L.) Ait. with Potent Cytotoxicity against MCF-7 Cell Lines.

A new triterpenoid was isolated from the roots of (L.) Ait. Its structure was elucidated by 1D and 2D NMR analysis, single crystal X-ray diffraction, and HRESIMS.

A Review on Shikonin and Its Derivatives as Potent Anticancer Agents Targeted against Topoisomerases.

The topoisomerases (TOPO) play indispensable roles in DNA metabolism, by regulating the topological state of DNA. Topoisomerase I and II are the well-established drug-targets for the development of anticancer agents and antibiotics. These drugs-targeting enzymes have been used to establish the relationship between drug-stimulated DNA cleavable complex formation and cytotoxicity.

Isolation, structural elucidation of new phytoecdysteroids from Ajuga decumbens Thunb.

Five new phytoecdysteroids (1, 2, 3, 4, and 5) were isolated from Ajuga decumbens Thunb. planted at Pingtan island of Fujian Province. Their structures were elucidated by NMR(H NMR, C NMR, DEPT, HMBC, HSQC, H-H COSY, ROESY), and HRESIMS.

New -Clerodane Diterpenoids Isolated from Thunb., Planted at Pingtan Island of Fujian Province with the Potent Anticancer Activity.

Aims: The aim of this study is to find the anticancer lead compounds or drug candidates from Chinese Traditional Plant Medicine of Ajuga decumbens Thunb.

Background: Ajuga decumbens Thunb. has been used in clinical for a long time in China and was selected in "Chinses Pharmacopoeia" (part I in 1977) for its wide spectrum biological activities: such as anticancer, antioxidant, antifeedant, antibacterial, anti-inflammatory, antihyperlipidemic, anti-cholinesterase and cytotoxicity activities.

An Overview of Dihydroartemisinin as a Promising Lead Compound for Development of Anticancer Agents.

Dihydroartemisinin (DHA) is a derivative of artemisinin, which firstly showed higher antimalarial activity. Over the years, DHA has also been discovered to exhibit higher anticancer efficacy without adverse side effects. Although some shortcomings have been discovered during biological evaluation (such as poor aqueous solubility, short half-life, and initial burst release effect), several attempts have been developed to overcome these shortcomings.

The Progress of the Anticancer Agents Related to the Microtubules Target.

Anticancer drugs based on the microtubules target are potent mitotic spindle poison agents, which interact directly with the microtubules, and were classified as microtubule-stabilizing agents and microtubule-destabilizing agents. Researchers have worked tremendously towards the improvements of anticancer drugs, in terms of improving the efficacy, solubility and reducing the side effects, which brought about advancement in chemotherapy. In this review, we focused on describing the discovery, structures and functions of the microtubules as well as the progress of anticancer agents related to the microtubules, which will provide adequate references for researchers.