Publications by authors named "Olaf Christian Bressel"
It is known since 1996 that mouse odorant receptors (ORs) are involved in determining the positions of the sites of coalescence of axons of olfactory sensory neurons (OSNs)-the thousands of glomeruli in the olfactory bulb. But the molecular and cellular mechanisms of OR-mediated axonal coalescence into glomeruli remain unclear. A model was proposed in 2006-2009 whereby OR-derived cAMP signals, rather than direct action of OR molecules, determine the target destinations (glomeruli) of OSNs in the bulb.
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- The main olfactory system in mice uses approximately 1,100 odorant receptor genes to help millions of olfactory sensory neurons communicate scents, which converge into around 3,600 glomeruli in the olfactory bulb.
- The study involved counting all fluorescently tagged olfactory sensory neurons across 15 gene-targeted strains to better understand their distribution, resulting in a total cell count of 685,673 across 56 mice.
- The researchers found significant variability in olfactory sensory neuron numbers among different odorant receptor genes and established a strong link between the number of olfactory sensory neurons and the total volume of the glomeruli formed by their axons, suggesting volume measurement could serve as a proxy for estimating these neuron counts.