Publications by authors named "Olaejirinde O Olaofe"
Background: p53 is a tumor suppressor gene. p53 expression in epithelial ovarian tumors (EOTs) is correlated with their biological behavior and predicts patient overall survival. However, there is a dearth of knowledge regarding p53 expression in these tumors among women from southwest Nigeria.
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- - This case report describes a rare instance of metastatic signet ring carcinoma in the ovary of a 46-year-old Black African woman, occurring alongside a benign fibroma, highlighting the complexity of ovarian lesions.
- - The patient experienced significant abdominal swelling and was found to have a large mass in the right ovary, along with signs of metastasis in the lungs and liver, as indicated by imaging and elevated tumor markers (CA 125 and CA 19-9).
- - Surgical intervention involved a total abdominal hysterectomy and bilateral salpingo-oophorectomy, revealing a mix of spindle cells and signet ring cells in the ovarian tissues, illustrating the unique histological findings associated with this case.
Article Synopsis
- Sebaceous carcinoma is a rare aggressive tumor of skin glands, with no cases reported in the last decade at one medical center, particularly among Black Africans.
- A 55-year-old African man experienced a growth on his eyelid for 8 months, which bled spontaneously, following a history of rectal cancer treatment.
- The tumor was diagnosed as sebaceous carcinoma through histological examination after surgical excision, and the patient is currently doing well.
Immediate lymph node extraction improves retrieval rate following axillary lymph node dissection: an effective approach to improving guideline-concordant breast cancer care in Nigeria.
Ecancermedicalscience
October 2023
Background: Axillary lymph node staging is essential for making therapeutic decisions and for prognostication. A minimum of ten lymph nodes is recommended for accurate staging. This study describes the process and outcomes of an audit cycle that resulted in a novel intervention instituted to improve concordance with guidelines.
View Article and Find Full Text PDFMultiple components of the SUMOylation machinery are deregulated in various cancers and could represent potential therapeutic targets. Understanding the role of SUMOylation in tumor progression and aggressiveness would increase our insight in the role of SUMO in cancer and clarify its potential as a therapeutic target. Here we investigate SUMO in relation to conventional chondrosarcomas, which are malignant cartilage forming tumors of the bone.
View Article and Find Full Text PDFThe study is a retrospective cross-sectional study carried out in the Department of Pathology of Premier Hospital, Abuja, on specimens received over a one-year period. Four hundred and eighty-six samples of endometrial biopsies and curettings from women presenting with abnormal uterine bleeding sent to the histopathology laboratory were analyzed. The most common biopsies were those of product of conception which accounted for 304 cases (62.
View Article and Find Full Text PDFIntroduction: Although it is a well recognized premalignant lesion of the stomach, there is a dearth of information on the clinicopathologic features of gastric intestinal metaplasia in Nigerians. It is, therefore, necessary to study these features and their possible contribution to the development of gastric carcinoma in Nigerians.
Methods: All gastric biopsies with the histo-morphologic features of intestinal metaplasia diagnosed at the department of morbid anatomy and forensic medicine, Obafemi Awolowo university teaching hospitals complex, Ile-Ife, Nigeria between January 2006 and December 2010 were used for the study.
Aim. The aim of this study was to carry out a retrospective clinicopathological analysis of the ocular lesions requiring biopsy seen in the Department of Histopathology, Federal Medical Centre (FMC), Keffi, in North Central Nigeria. Materials and Method.
View Article and Find Full Text PDFIntroduction: The aim of this study is to retrospectively assess the prevalence of some of skin malignancies in our environment and to provide a data base for creating awareness for prevention and early detection of the diseases in order to reduce morbidity and mortality associated with these skin lesions in our environment.
Methods: This is a retrospective study of all histologically diagnosed malignant skin lesions which presented at Ladoke Akintola University of Technology Teaching Hospital Osogbo Osun State between January 2006 and December 2010.
Results: Ninety- eight patients presented with skin cancers out of which 60 (61.
Aim: Maternal mortality is a major health problem, especially in Nigeria, where accurate autopsy-based data on the prevalent causes are not readily available. The aim of this study was therefore to accurately determine the causes of maternal death as seen in a tertiary health facility in Nigeria.
Materials And Methods: This was a descriptive, retrospective review of the postmortem autopsy findings from cases of maternal death at the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria over a 5-year period.