Quality assessment of platelet concentrate prepared at a tertiary centre in Nigeria.

The need for platelet transfusion has increased at the University College Hospital (U.C.H.

Coagulation profile in healthy Nigerian neonates.

A study of some coagulation factors were carried out in preterm and term infants on the first day of life. Screening coagulation tests--prothrombin time (PT), partial thromboplastin time with kaolin (PTTK) and the concentrations of Factors VIII: C and fibrinogen were determined in 100 normal newborn infants classified into three groups according to their gestational ages: 28 to 30 weeks, 31 to 36 weeks, 37 to 42 weeks. The respective values were compared with those of six-month-old infants as well as adults.

Haematological values in pregnancy in Ibadan, Nigeria.

Haematological values were studied in 495 apparently healthy pregnant Nigerian women receiving antenatal care in a maternity hospital in Ibadan, Nigeria. Means, standard deviations and ranges of haematrocrit, total and differential white cell counts, absolute platelet count, erythrocyte sedimentation rte, prothrombin time (PT) and partial thromboplastin time (PTTk) were determined. The mean haematrocrit was 0.

Septicaemia in sickle cell anaemia patients: the Ibadan experience.

Objective: To describe the pattern of septicaemia among sickle cell anaemia patients.

Design: Descriptive study.

Setting: Haematology Day Care Unit of the University College Hospital, Ibadan, Nigeria.

Acceptability of prenatal diagnosis of sickle cell anaemia by a sample of the Nigerian population.

The acceptability of prenatal diagnosis (PND) as a means of controlling sickle cell anaemia (SCA) in Nigeria was examined using a semi-structured questionnaire. The aim of the study was to examine the attitudes of well-informed, educated Nigerians to the use of PND and abortion of confirmed HbSS pregnancies in the control of SCA. There were 433 respondents comprising 204 males and 210 females (gender was not recorded for 19 respondents).

Ferritin and serum iron levels in adult patients with sickle cell anaemia at Ibadan, Nigeria.

The ferritin and serum iron levels in 100 adult patients with sickle cell anaemia (SCA) and in ten pregnant (SCA) females were measured. All the adult sickle cell anaemia patients had serum ferritin levels ranging between 325 ng/dl and > 1500 ng/dl. These levels are within and above the normal range.

Neurological manifestations of chronic myelogenous leukaemia.

Neurological manifestations occur in about one-quarter of patients with chronic myelogenous leukaemia (CML), usually as a result of hyperleukocytosis, predisposing to intravascular thrombus formation. We report the clinical and pathological findings in a 16-year-old female with CML who presented with deafness, blindness and paraplegia, and discuss possible aetiopathogenetic mechanism.

Bacterial causes of acute osteomyelitis in sickle cell anaemia: changing infection profile.

The bacterial causes of osteomyelitis were reviewed on 25 patients with sickle cell anaemia using blood culture and direct wound swab. Age range was 2 to 45 years with a median of 23 years. Klebsiella species were cultured in 45% of the blood samples.

Acceptability of prenatal diagnosis of sickle cell anaemia (SCA) by female patients and parents of SCA patients in Nigeria.

The acceptability of prenatal diagnosis (PND) of sickle cell anaemia (SCA) as a means of controlling sickle cell disorder in Nigeria was examined using a structured questionnaire. The respondents were comprised of 92 adult female patients with SCA, aged 15-20 (23 +/- 6) years; 53 HbAS mothers, aged 20-61 (37 +/- 11) years and 48 HbAS fathers, aged 33-65 (46 +/- 8) years. More than 85% of the respondents would like PND to be offered in Nigeria and 92% of the HbAS mothers as well as 86% of the fathers would like to have the investigation or allow their wives to go through the procedure, respectively.

A review of cephalhaematoma in adult sickle cell disease patients.

Twelve patients with sickle cell disease (SCD), eleven males within the age range 21 to 24 years and one female, fourteen years old presenting with cephalhaematoma at the Haematology Day Care Unit (H.D.C.

Aplastic anaemia: a review of cases at the University College Hospital, Ibadan, Nigeria.

Thirty male and 27 female patients were treated at the University College Hospital, Ibadan, over a 20 year period (January, 1971 to December, 1990) for aplastic anaemia. Age range was three months to 52 years with a median of 19 years. In 26 patients the aplasia could not be linked with a particular cause.

Prognosis of acute lymphoblastic leukaemia in Ibadan, Nigeria.

Patients with acute lymphoblastic leukaemia (ALL) seen in University College Hospital, Ibadan, Nigeria, still have low rates of complete remission and relatively short survival. Yet the overall prognosis was expected to have improved because the proportions of adults, males and people of low socio-economic class among the patients have decreased steadily over the past three decades. Possible causes of the persistent poor performance were sought for in 30 new ALL patients seen in the hospital over a period of 2 years and 9 months.