Unexpected Growth of Small Right Ventricle After Failed Repair of Atrioventricular Septal Defect.

Unbalanced atrioventricular septal defect with hypoplastic right ventricle in infants with trisomy 21 poses significant challenges as they are not ideal candidates for single-ventricle palliation. We describe a patient with the diagnoses who underwent a biventricular repair but subsequently required a Blalock-Thomas-Taussig shunt (BTTS) with enlargement of atrial communication because of severe right-sided heart failure and low cardiac output. Staged device embolization of the BTTS and atrial communication were achieved by 7 years of age.

Impact of effluents from a closed mine on the surrounding water resources: Groundwater contamination of the historical abandoned mine site in Japan.

The extraction of mineral deposits is often associated with the occurrence of acid mine drainage (AMD), which can persist even after mine closure due to remaining sulfide minerals. This study investigates a 200-year-old abandoned mine and its impacts on nearby water resources. The study area is well known for Kuroko ore deposits located upstream of spring and river water resources.

Framework for developing self-actualization skills in young adults with autism.

Purpose: Young adults with autism spectrum disorder (YAASD) often lack the skills needed for successful adult living and subsequently develop lower quality of life and health in adulthood. Therefore, we developed a framework to support resilience and improve quality of life in YAASD, which will be used to develop a life-skills curriculum for YAASD.

Methods: We conducted a qualitative study of YAASD, parents of YAASD and service providers recruited from agencies that serve YAASD using Grounded Theory.

[Quantitative Analysis and Characteristics of Salmonella from Retail Chicken Meat Products in Japan].

From October 2020 to February 2021, a total of 95 retail chicken meat products from 39 retail meat shops in Tokyo Metropolis and Kanagawa Prefecture, Japan, were collected and examined for the prevalence of Salmonella to assess public health implications. If a sample tested positive for Salmonella, a quantitative analysis was performed using the three-tube most probable number (MPN) method. Of 95 retail chicken meat products, Salmonella was isolated from 30 samples (31.

2024 Update of the RECOVER-Adult Long COVID Research Index.

Importance: Classification of persons with long COVID (LC) or post-COVID-19 condition must encompass the complexity and heterogeneity of the condition. Iterative refinement of the classification index for research is needed to incorporate newly available data as the field rapidly evolves.

Objective: To update the 2023 research index for adults with LC using additional participant data from the Researching COVID to Enhance Recovery (RECOVER-Adult) study and an expanded symptom list based on input from patient communities.

Pediatric Subspecialist Referrals to Peer Support for Families.

Background And Objectives: Families of children with special health care needs (CSHCN) have reported to benefit from social, emotional, and informational support from other families (peer support) with similarly affected children. Pediatric subspecialists often serve as the primary medical providers for CSHCN, as well as educators for these children's families. The extent to which subspecialists refer families to sources of peer support is unknown.

A Case of Advanced Extramammary Paget's Disease With a High Tumor Mutation Burden That Showed Partial Lymph Node Regression With Pembrolizumab.

Pembrolizumab has been found effective against various solid tumors with high tumor mutation burden, but there are no reports of successful treatment with pembrolizumab for extramammary Paget's disease (EMPD) with a high tumor mutation burden (TMB). This report describes a 71-year-old male patient who presented with irregularly shaped erythematous lesions on his scrotum, which had been there for several years. He was diagnosed with EMPD.

Unraveling the DNA methylation landscape in dog blood across breeds.

Background: DNA methylation is a covalent bond modification that is observed mainly at cytosine bases in the context of CG pairs. DNA methylation patterns reflect the status of individual tissues, such as cell composition, age, and the local environment, in mammals. Genetic factors also impact DNA methylation, and the genetic diversity among various dog breeds provides a valuable platform for exploring this topic.

cGMP-dependent pathway and a GPCR kinase are required for photoresponse in the nematode Pristionchus pacificus.

Light sensing is a critical function in most organisms and is mediated by photoreceptor proteins and phototransduction. Although most nematodes lack eyes, some species exhibit phototaxis. In the nematode Caenorhabditis elegans, the unique photoreceptor protein Cel-LITE-1, its downstream G proteins, and cyclic GMP (cGMP)-dependent pathways are required for phototransduction.

Harnessing Free Sulfate Groups in Glycosylation Reactions.

General strategies for synthesizing sulfated oligosaccharides employ the protection of sulfate groups for glycosylation or post-sulfation after the synthesis of oligosaccharides. However, the chemical behavior of free sulfate groups in glycosylation reactions has not been thoroughly studied. We examined several glycosyl donors with free sulfate groups, but neither glycosyl imidates nor thioglycosides achieved products.

Diverse antifungal potency of terbinafine as a therapeutic agent against Exophiala dermatitidis in vitro.

Exophiala dermatitidis (E. dermatitidis), which causes skin or respiratory disease, is occasionally fatal in immunocompromised patients. Here, we report the unique antifungal potency of terbinafine (TRB), which targets squalene epoxidase, against E.

ER Oxidoreductin 1-Like Activity of Cyclic Diselenides Drives Protein Disulfide Isomerase in an Electron Relay System.

Disulfide formation generally involves a two-electron oxidation reaction between cysteine residues. Additionally, disulfide formation is an essential post-translational modification for the structural maturation of proteins. This oxidative folding is precisely controlled by an electron relay network constructed by protein disulfide isomerase (PDI), with a CGHC sequence as the redox-active site, and its family enzymes.

Insights of the peroxychloroformyl radical ClC(O)OO microwave spectrum.

The exploration of Venus has received much attention in the past and will keep growing due to the starting of the NASA DAVINCI project. To explain the extremely low O : CO ratio observed in Venus' atmosphere, a chlorine-initiated CO oxidation catalytic cycle has been proposed. However, relevant studies on the key intermediates, such as the peroxychloroformyl radical (ClC(O)OO), are rare.

Anti-VEGFR2 neutralising antibody slows the progression of multistep oral carcinogenesis.

Angiogenesis plays an important role in cancer growth and metastasis, and it is considered a therapeutic target to control tumour growth following anti-angiogenic therapy. However, it is still unclear when tissues initiate angiogenesis during malignant transformation from premalignant condition and whether this premalignant condition could be a therapeutic target of anti-angiogenic therapy. In this study, we aimed to analyse the onset of angiogenesis by evaluating morphological and functional alterations of microvessels during oral multistep carcinogenesis using a 4-nitroquinoline 1-oxide (4NQO)-induced oral carcinogenesis mouse model.

Secretion of endoplasmic reticulum protein VAPB/ALS8 requires topological inversion.

VAMP-associated protein (VAP) is a type IV integral transmembrane protein at the endoplasmic reticulum (ER). Mutations in human VAPB/ALS8 are associated with amyotrophic lateral sclerosis (ALS). The N-terminal major sperm protein (MSP) domain of VAPB (Drosophila Vap33) is cleaved, secreted, and acts as a signaling ligand for several cell-surface receptors.

Intracranial atherosclerotic disease mechanism indicates poor outcomes of thrombectomy in acute cerebral infarction with large vessel occlusion: A matched cohort study.

Background: Thrombectomy is a standard treatment for acute large vessel occlusion (LVO); however, its effectiveness in treating LVO related to intracranial atherosclerosis disease (ICAD) remains uncertain. This study aimed to compare thrombectomy outcomes in ICAD-related and embolic LVO, focusing on patients with similar symptom severities upon hospital admission.

Methods: This retrospective study was conducted at Jikei University Hospital and Jikei University Kashiwa Hospital between October 2017 and March 2023.

Cerebral Small Vessel Disease is Associated with Prehospital Delay in Acute Ischemic Stroke.

Aim: To determine whether the severity of cerebral small vessel disease (SVD) is associated with prehospital delay in acute ischemic stroke.

Methods: Consecutive patients with ischemic stroke were included in this study. We evaluated the SVD burden using the total SVD score.

Association of severe hyposmia and frontal lobe dysfunction in patients with Parkinson's disease.

Backgrounds And Objectives: Severe hyposmia (SH) is a prodromal symptom of dementia associated with Parkinson's disease (PD) caused by Lewy bodies deposited in the limbic regions that connect the frontal and temporal lobes. We aimed to clarify the association between hyposmia and frontal lobe dysfunction (FLD) among patients with PD.

Methods: Patients with PD and Hoehn & Yahr stage 1-3 at on-periods without apparent dementia were screened.

Impact of Hemoglobin Level in Ex Vivo Heart Perfusion on Donation After Circulatory Death Hearts: A Juvenile Porcine Experimental Model.

Background: Ex vivo heart perfusion (EVHP) of donation after circulatory death (DCD) hearts has become an effective strategy in adults; however, the small circulating volume in pediatrics poses the challenge of a low-hemoglobin (Hb) perfusate. We aimed to determine the impact of perfusate Hb levels during EVHP on DCD hearts using a juvenile porcine model.

Methods: Sixteen DCD piglet hearts (11-14 kg) were reperfused for 4 h in unloaded mode followed by working mode.