Publications by authors named "Okubo M"

Background: Chest compressions are life-saving in cardiac arrest but concern by layperson of causing unintentional injury to patients who are not in cardiac arrest may limit provision and therefore delay initiation when required.

Aim: To perform a systematic review of the evidence to identify if; among patients not in cardiac arrest outside of a hospital, does provision of chest compressions from a layperson, compared to no use of chest compressions, worsen outcomes.

Method: We searched Medline (Ovid), Web of Science Core Collection (clarivate) and Cinahl (Ebsco).

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Background: The angiography-derived non-hyperemic pressure ratio (angioNHPR) is a novel index of NHPR based on artificial intelligence (AI) that does not require pressure wires. We investigated the diagnostic accuracy of angioNHPR for detecting hemodynamically relevant coronary artery disease.

Methods And Results: In this retrospective single-center study, angioNHPR was assessed using the invasive NHPR as the reference standard.

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Background: Diffusion-weighted magnetic resonance imaging (DWI) is essential for diagnosing Creutzfeldt-Jakob disease (CJD). Thalamic lesions are rarely detected by DWI in sporadic CJD (sCJD) cases with methionine homozygosity at polymorphic codon 129 (129MM) of the prion protein (PrP) gene. Here, we describe an unusual sCJD case, characterized by prolonged isolated thalamic diffusion hyperintensities and atypical brain pathology, in combination with the 129MM genotype.

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Importance: Little is known about the epidemiology of out-of-hospital cardiac arrest (OHCA) in patients with asystole in countries where prehospital resuscitation is not withheld or terminated.

Objective: To investigate the secular trends in the patient outcomes and advanced life support (ALS) procedures and evaluate the association of ALS procedures with favorable outcomes among patients with OHCA and asystole.

Design, Setting, And Participants: This cohort study analyzed data from a nationwide prospective OHCA registry in Japan.

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Transition-metal oxyhydrides are an emerging class of functional materials; however, the known compounds have mostly been limited to perovskite-type sturctures. Here, we successfully synthesized LiNbHO, the first example of a rock-salt-type transition-metal oxyhydride, using mechanochemical methods. Galvanostatic charge/discharge tests revealed that LiNbHO functions as an electrode for lithium secondary batteries.

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Background: The Direct Oral Anticoagulant (DOAC) Score can predict bleeding risk in patients with atrial fibrillation taking DOACs; however, it lacks external validation. Therefore, this study aimed to assess the association between the DOAC Score and bleeding events in patients with atrial fibrillation who underwent transcatheter aortic valve replacement.

Methods And Results: This retrospective multicenter cohort study included patients with atrial fibrillation who underwent transcatheter aortic valve replacement, as registered in a Japanese multicenter registry.

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Article Synopsis
  • The research investigated the impact of the order in which vasopressors and advanced airway management are administered during out-of-hospital cardiac arrest (OHCA) on patient outcomes, specifically looking at data from the Pragmatic Airway Resuscitation Trial (PART).
  • Out of 3,004 patients from the trial, the analysis focused on 2,404 individuals, finding no significant difference in survival rates or return of spontaneous circulation based on whether vasopressors or advanced airway interventions were performed first.
  • The study concluded that the sequence of administering vasopressors and airway management did not affect patient outcomes or the quality of CPR delivered during resuscitation efforts.
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Background: The superficial temporal artery-middle cerebral artery (STA-MCA) bypass surgery requires an anastomosis of the STA to an MCA with diminished blood flow. However, identifying the precise location of the MCA with reduced flow preoperatively is challenging as it often remains nonvisualized. To address this issue, we developed a novel technique, the area target bypass (ATB) method, to infer the location of the responsible vessel for low-flow areas.

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The size of the ovarian reserve, an indicator of the number of primordial follicles, varies widely among individuals, and declines with age. However, the association between the ovarian reserve and fertility remains unclear. Therefore, in the present study, we analyzed the relationship between plasma concentrations of anti-Müllerian hormone (AMH), a marker of ovarian reserve, and reproductive outcomes in Japanese Black cattle.

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Article Synopsis
  • All-solid-state batteries utilize nonflammable inorganic solid electrolytes to enhance safety compared to traditional lithium-ion batteries that use flammable liquid electrolytes.
  • Conventional electrode materials face significant volume changes during lithium ion movement, leading to mechanical failures and reduced performance.
  • This study introduces MXenes, which maintain structural stability during lithium (de)intercalation, resulting in a strain-free solid-state battery that shows improved long-term stability and maintains effective interface contact between the electrodes and solid electrolytes.
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  • The study aimed to develop a real-time measurement of fractional flow reserve (FFR) using intravascular ultrasound (IVUS), which improves upon traditional offline methods that take about 10 minutes.
  • It involved analyzing coronary lesions with at least 25% stenosis, taking measurements of IVUS and FFR before and after stent placement.
  • Results showed a strong correlation (r=0.896) between the newly developed IQ-FFR and traditional wire-derived FFR, indicating high accuracy (87.5%) in predicting post-stent FFR levels, making IQ-FFR a promising tool for assessing coronary lesions.
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Objective: To develop a translation between the Glasgow Come Scale and the Alert-Verbal-Pain-Unresponsive (AVPU) scale among adults with out-of-hospital emergencies.

Methods: We performed a retrospective analysis of adults (≥18 years) from the 2022 National Emergency Medical Services (EMS) Information System with a ground scene encounter with a concurrently documented GCS and AVPU assessment. Using a training partition of 2.

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  • The study investigates the effectiveness and patient satisfaction of long-acting antiretroviral therapy (ART) using cabotegravir (CAB) and rilpivirine (RPV) for individuals living with HIV who switched from conventional treatments.
  • Thirty-eight male participants were monitored for 44 weeks after switching, with results showing that all maintained viral suppression and experienced increased treatment satisfaction.
  • Additionally, the method demonstrated a small decrease in creatinine levels while lipid and glucose profiles remained stable, suggesting long-acting ART may enhance both health outcomes and patient well-being.
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 Job satisfaction is a professional aspect that contributes to the achievement of objectives in general and in the health sector; it is a golden standard for having quality care. The satisfaction of nurses is a path toward humanized nursing. This article aims to evaluate the job satisfaction among nurses of the neurosurgery department at Bantane Hospital.

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Article Synopsis
  • A case study describes a 57-year-old woman with a small, unruptured A1 aneurysm located on the posterior surface, which presented surgical challenges due to multiple perforators nearby.
  • Treating these rare aneurysms requires careful consideration to avoid neurological deficits, highlighting the importance of understanding their unique anatomical features.
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Managing safety and supply-chain risks associated with lithium-ion batteries (LIBs) is an urgent task for sustainable development. Aqueous proton batteries are attractive alternatives to LIBs because using water and protons addresses these two risks. However, most host materials undergo large volume changes upon H intercalation, which induces intraparticle cracking to accelerates parasitic reactions.

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Purpose: The aim of this study was to determine the incidence of the Amalric triangular sign (ATS) in patients with central retinal artery occlusion and investigate its association with visual function and carotid Doppler ultrasonography findings.

Methods: A retrospective chart review was conducted on 21 eyes from 21 patients with complete central retinal artery occlusion. Best-corrected visual acuity and carotid Doppler ultrasonography findings [peak systolic velocity, end-diastolic velocity, and resistance index (RI) = (PSV - EDV)/PSV] were investigated.

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  • This study examined how central sensitization symptoms relate to pain perception in patients with chronic masticatory myofascial pain transitioning from acute to chronic stages.
  • Researchers tested 23 patients with myofascial pain and 22 healthy volunteers, measuring pain thresholds and central sensitization using various assessments.
  • Results indicated that patients with chronic pain had lower pain thresholds but no correlation between central sensitization scores and pain perception, suggesting that central sensitization might occur before visible symptoms appear.
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We conducted an online questionnaire survey to investigate changes in well-being and anxiety in patients with hepatocellular carcinoma requiring repeated locoregional therapy(hepatectomy/ablation)and the differences between patients' and treating physicians' perceptions of what is important to patients when selecting treatment. Between December 2022 and January 2023, we collected responses from 162 patients and 115 physicians in Japan. Results showed no clinically significant changes in well-being over time.

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Aggressive mature T-cell lymphoma (TCL) is a disease that carries a poor prognosis. We analyzed the expression of 22 tumor cell functional proteins in 16 randomly selected patients with TCL. Immunohistochemistry was performed in paraffin-embedded tumor tissue sections to determine the protein expression statuses in tumor cells.

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Background And Aims: Early gastric cancers (EGCs) after Helicobacter pylori (H. pylori) eradication often appear as reddish depressed lesions (RDLs); the same features are also appeared in benign stomachs after eradication. We compared clinic-pathological and endoscopic features of benign and neoplastic RDLs after H.

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Although anti-Müllerian hormone (AMH) is involved in the regulation of granulosa cell function in female animals, its role in tissues other than ovarian follicles remains poorly understood. It has also been suggested that cows with high circulating AMH concentrations have increased fertility; however, the mechanism has not been elucidated. This study was conducted to identify the presence of the AMH-signaling system and its target cells in the bovine corpus luteum formed from an ovulated follicle.

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Article Synopsis
  • This study investigated repeat expansion in patients with adult-onset cerebellar ataxia, focusing on the differences between Japanese and non-Japanese populations.
  • The researchers used nanopore sequencing to analyze samples from 460 Japanese patients and various control groups, finding that different repeat motifs (GCA in Japanese vs. GGA in non-Japanese) affect pathogenicity.
  • Ultimately, the study highlights how unique features of repeat expansion and genetic background contribute to the prevalence of the disease in different ethnic groups.
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Background: Dynamic navigation for implant placement is becoming popular under the concept of top-down treatment. The purpose of this study is to verify the accuracy of a dynamic navigation system for implant placement.

Methods: Implant placement was performed on 38 patients using 50 implant fixtures.

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