Publications by authors named "Oktawia Fijalkowska"
ACP-105 is a novel non-steroidal Selective Androgen Receptor Modulator (SARM) used by athletes. Its action aims to increase muscle mass and is one of the options in testosterone replacement therapy. Its safety profile remains insufficiently explored, particularly regarding its toxicity in humans.
View Article and Find Full Text PDFAcovenoside A, a cardenolide glycoside from Acokanthera oppositifolia, demonstrates significant therapeutic potential in cardioprotection and oncology, particularly against non-small cell lung cancer (NSCLC). However, its toxicological profile requires thorough evaluation for safe pharmaceutical application. For this purpose a comprehensive in silico methods were applied, including ACD/Labs Percepta, STopTox, admetSAR 3.
View Article and Find Full Text PDFArticle Synopsis
- The study explores how magnetite nanoparticles (FeO NPs), when modified with dextran and glucosamine-based amorphous carbon, can combat drug-resistant senescent breast cancer cells.
- The FeO@aC nanoparticles were found to reduce reactive oxygen species, increase antioxidant proteins, and trigger markers for inflammation, autophagy, and apoptosis in cancer cells stimulated by chemotherapy.
- The researchers suggest that these modified FeO NPs can enhance reductive stress and cytotoxic effects, potentially offering a new strategy for treating both senescent and nonsenescent breast cancer cells.