The Effect of Smooth Muscle Cells and Leukocytes on HSV-1 Reproduction in Cultured Human Endothelial Cells.

The ability of intima smooth muscle cells (SMCs) and blood leukocytes to control the development of Herpes simplex type 1 virus (HSV-1) infection in human vascular endothelial cells (ECs) was studied under a co-culture conditions. It was shown that cultured ECs supported HSV-1 reproduction followed by cytopathogenic effect (CPE) and accumulation of infectious virus in the cell culture medium. At the multiplicity of infection (MOI) ranging from 1 to 0.