THE MODIFYING ROLE OF TOXIC SUBSTANCES ON GENOTOXIC EFFECT IN THE BODY DURING COMBINED ADMINISTRATION WITH CARCINOGEN (BENZO[A]PYRENE).

Objective: The aim: of this work was to experimentally study the modifying role of toxic substances (phenol) in the manifestation of genotoxic and immunological changes in the body when exposed to a carcinogen (benzo[a]pyrene).

Patients And Methods: Materials and methods: Investigations were carried out in the chronic experiment on white random-bred male mice. Genotoxic (micronucleus test), immunologic and pathomorphological methods were used.

On the issue of accelerated hygienic assessment of environmental genotoxic carcinogens.

Objective: The aim of the work was assessment of the criterial significance of the complex of early immunological reactions of the organism, pathomorphological and genotoxic changes in the organs for the acceleration of testing and hygienic assessment of carcinogenic danger of chemical substances.

Patients And Methods: Materials and methods: Investigations were carried out in the chronic experiment on white random-bred male mice and included 2 series of the investigations: 1 - application of benz(a)pyrene on skin in different doses (10.5µg; 2.