Publications by authors named "Oksana S Patrusheva"
Article Synopsis
- * This study explores reactions between salicylic aldehydes and a specific monoterpene derivative, resulting in various chiral polycyclic products, with some being novel ring structures.
- * The results indicate that the type of acid catalyst used and the reaction conditions significantly influence the product outcomes, and the study includes detailed mechanistic insights supported by experimental and computational methods.
We synthesized fluoro- and hydroxy-containing octahydro-2H-chromenes by the Prins reaction starting from a monoterpenoid (-)-isopulegol and a wide range of aromatic aldehydes in the presence of the BF∙EtO/HO system acting as both an acid catalyst and a fluorine source. Activity of the produced compounds against the influenza A/Puerto Rico/8/34 (H1N1) virus was studied. The highest activity was demonstrated by fluoro- (11i) and hydroxy-containing (10i) derivatives of 2,4,6-trimethoxybenzaldehyde.
View Article and Find Full Text PDFA Novel Small Molecule Supports the Survival of Cultured Dopamine Neurons and May Restore the Dopaminergic Innervation of the Brain in the MPTP Mouse Model of Parkinson's Disease.
ACS Chem Neurosci
October 2019
Article Synopsis
- Researchers synthesized new compounds called monoepoxides from a previously studied monoterpenoid that reduced Parkinson's disease symptoms in animal models.
- One specific epoxide was identified that effectively restored movement in mice with Parkinson's and successfully crossed the blood-brain barrier.
- This epoxide showed strong protective effects on dopamine neurons and could promote the regrowth of these neurons, suggesting its potential as both a treatment and a neuroprotective drug for Parkinson's disease.
The antiviral activity of 4-hydroxy-hexahydro-2H-chromenes and 4-fluorine-hexahydro-2H-chromenes with an aromatic substituent, synthesized from monoterpene (-)-verbenone, was studied for the first time. Five of 11 (45 per cent) of 4-hydroxy-hexahydro-2H-chromene-type compounds have been found to exhibit antiviral activity against influenza A virus of subtype H1N1pdm09. Although a portion of active compounds among 4-fluorine-containing series was fewer, just compound 5i that contains a fluorine substituent exhibited more potent anti-influenza activity along with low cytotoxicity.
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