Publications by authors named "Oksana Rymar"
Background: It is important to determine the influence of traditional risk factors on the development of type 2 diabetes mellitus (T2DM) in young adults. Goal of the research: To study the incidence of T2DM and factors that increase the risk of its occurrence during the observation of a cohort of young adults.
Materials And Methods: 1341 people aged 25-44 were included in the study from 2013 to 2017, of whom 622 were men (46.
During differential diagnosis of diabetes mellitus, the greatest difficulties are encountered with young patients because various types of diabetes can manifest themselves in this age group (type 1, type 2, and monogenic types of diabetes mellitus, including maturity-onset diabetes of the young (MODY)). The MODY phenotype is associated with gene mutations leading to pancreatic-β-cell dysfunction. Using next-generation sequencing technology, targeted sequencing of coding regions and adjacent splicing sites of MODY-associated genes (, , , , , , , , , , , , , and ) was carried out in 285 probands.
View Article and Find Full Text PDF. To study the associations of risk factors for chronic non-communicable diseases (CNCDs) and osteoporotic fractures (OFs) in a population sampling over 50 years. .
View Article and Find Full Text PDFThe first all-Russia conference with international participation, "Basic Research in Endocrinology: A Modern Strategy for the Development and Technologies of Personalized Medicine", was held in Novosibirsk on 26-27 November 2020. [..
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- * Findings: Significant risk factors for T2DM included high BMI, abdominal obesity, fasting hyperglycemia, high triglycerides, hypertension, and family history of diabetes. Secondary education, low physical activity, and cardiovascular disease history were also notable for females.
- * Tool Development: A T2DM risk calculator was created based on simple, non-laboratory parameters like waist circumference, hypertension history, and family diabetes history, providing an effective way to identify individuals at
Article Synopsis
- - Maturity onset diabetes of the young (MODY) is a genetic form of diabetes that appears in young individuals, caused by defects in pancreatic beta-cell function, with 14 known subtypes linked to specific gene mutations.
- - The most common MODY subtypes are linked to mutations in genes such as HNF1A, GCK, and HNF4A, with up to 70% of cases arising from HNF1A and HNF4A mutations.
- - In a study of 178 patients in Western Siberia, novel mutations were identified in several MODY genes among 38 individuals, highlighting the genetic diversity and complexity of this condition.
Article Synopsis
- * Researchers analyzed a group of 151 patients with MODY and found 13 variants; one specific variant, rs11544593, was significantly more common in the MODY patients compared to a control group.
- * The study suggests that the rs11544593 variant may affect blood glucose levels and could have implications for understanding carbohydrate metabolism issues in MODY patients.
The reduction in bone and muscle mass increases in menopausal women and poses a threat to the loss of - in the elderly. The aim of the study was to assess the frequency of osteoporotic forearm fractures (OFF) in postmenopausal women and to study their association with risk factors for chronic non-communicable diseases (NCD). The study was based on the Russian arm of the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) project (Novosibirsk).
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- This article details a case of MODY12 caused by a mutation in the ABCC8 gene, presenting in a 27-year-old man with diabetes, epilepsy, and complications like retinopathy and hypoglycemia.
- The patient was successfully treated with gliclazide and SGLT2 inhibitors after insulin therapy was stopped, leading to improved blood sugar control without further hypoglycemic episodes.