Publications by authors named "Oksana Kasianenko"
Background: The infection of bovine mammary glands by pathogenic microorganisms not only causes animal distress but also greatly limits the development of the dairy industry and animal husbandry. A deeper understanding of the host's initial response to infection may increase the accuracy of selecting drug-resistant animals or facilitate the development of new preventive or therapeutic intervention strategies. In addition to their functions of milk synthesis and secretion, bovine mammary epithelial cells (BMECs) play an irreplaceable role in the innate immune response.
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- BSN-37 is a novel antimicrobial peptide isolated from bovine spleen that shows antibacterial and immunomodulatory properties, prompting a study on its effects on mouse macrophages RAW264.7.
- The research involved using a whole gene expression microarray to identify differentially expressed lncRNAs and mRNAs following BSN-37 treatment, leading to the selection of eight lncRNAs and nine mRNAs for further validation through qRT-PCR.
- Results revealed significant changes, with 1294 lncRNAs and 260 mRNAs differing between treated and control groups, highlighting genes tied to immune responses, cell growth, and metabolism, and confirming the reliability of the data through qRT-PCR validation.