Publications by authors named "Oksana Hautzinger"
Maladaptive insulin signaling is a key feature in the pathogenesis of severe metabolic disorders, including obesity and diabetes. Enhancing insulin sensitivity represents a major goal in the treatment of patients affected by diabetes. Here, we identify transforming growth factor-β1 stimulated clone 22 D4 (TSC22D4) as a novel interaction partner for protein kinase B/Akt1, a critical mediator of insulin/phosphatidylinositol 3-kinase signaling pathway.
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- Cachexia is a severe energy-wasting syndrome commonly seen in cancer patients, leading to significant muscle and fat loss.
- Tumor exposure in mice initiated a cycle of energy loss in fat cells, marked by both fat breakdown and creation, alongside inactivated AMP-activated protein kinase (Ampk), which usually helps maintain energy levels.
- The introduction of an Ampk-stabilizing peptide (ACIP) showed promise in reducing fat wasting, suggesting that maintaining Ampk function could be a potential therapeutic approach for cachexia.