Changes in the Hematopoietic System and Blood Under the Influence of Heavy Metal Salts Can Be Reduced with Vitamin E.

Objective: The aim of our work was to study the blood parameters and bone marrow morphological changes in rats exposed to increased amounts of heavy metal salts and the effect of vitamin E.

Material And Method: Investigation of bone marrow structural features and blood parameters was performed in sexually mature Wistar male rats (n=84).

Results: Exposure to increased amounts of heavy metal salts led to the inhibition of erythropoiesis and leukopoiesis, as well as a synchronized increase in the number of megakaryocytes which was clearly reflected in the blood: the number of erythrocytes, leukocytes and Hb decreased, and the number of platelets increased.

Structural features of bone marrow.

Purpose: This article is devoted to the investigation of the structural features of the bone marrow of mature rats.

Materials And Methods: The investigation of the structural features of the bone marrow was performed on the femurs of the mature male rats. General structure of the organ was studied with hematoxylin-eosin and Van Gieson staining of samples.

Pathogenetic mechanisms of heavy metals effect on proapoptotic and proliferative potential of breast cancer.

Materials And Methods: Chemical composition was studied with the help of the scanning electron microscope with energy-dispersion spectrometer. Immunohistochemical reaction showed the p53 and Ki-67 receptors expression. The study of DNA fragmentation was performed in agarose gel.