Molecular-genetic characteristics of hmgb1 mrna expression in blood of women with endometriosis associated with infertility.

Objective: Aim: To examine HMGB1 expression in the blood of women with endometriosis-associated infertility and to establish its role in disease progression.

Patients And Methods: Materials and Methods: We analyzed HMGB1 gene expression levels in two groups: 20 women with endometriosis-associated infertility (main group) and 10 healthy women (control group). The study was conducted at Bukovinian State Medical University and the Centre of Reproductive Medicine.

Probiotics and NLRP3 mRNA inflammasome levels in women with endometriosis-related infertility undergoing assisted reproductive technologies.

This research was conducted at Bukovinian State Medical University and the Centre of Reproductive Medicine and included a total of 30 infertile women. The control group consisted of 10 women with tubal infertility resulting from a prior history of inflammation, who, following a comprehensive clinical and laboratory assessment, exhibited no other underlying health conditions and could be regarded as essentially healthy individuals. Participants in the control group ranged from 21 to 42 years, with an average age of 29.

INFLUENCE OF PROBIOTICS ON THE MESOTHELIN LEVEL IN WOMEN WITH ENDOMETRIOSIS ASSOCIATED WITH INFERTILITY IN COMPLEX PREPARATION FOR ASSISTED REPRODUCTIVE TECHNOLOGIES.

Objective: The aim: To study the determination of Mesothelin level in women with endometriosis associated with infertility and estimate influence of probiotic on endometriosis according of Mesothelin level in complex preparation before assisted reproductive technologies.

Patients And Methods: Materials and methods: In this study, we conducted a retrospective analysis of the medical records of 40 infertile women who underwent assisted reproductive technologies while also using the probiotic "Femina Probiz." We divided the participants into two groups.

Pregnancy and umbilical cord pathology: structural and functional parameters of the umbilical cord.

Scientific research in the field of physiology and pathology of the umbilical cord is quite limited and imperfect. The purpose of the study was to evaluate the histological architecture of the pathological umbilical cord and investigate the relationship between the main parameters and placental postnatal macromorphometric characteristics, which serve as a reflection of placental dysfunction. Four groups of patients were included, each undergoing a postnatal histological and topographic examination of the umbilical cord: Wharton's jelly edema (10 samples), velamentous cord insertion (10 samples), single umbilical artery (10 samples), and physiological pregnancy (10 samples).

Mueller-matrix imaging polarimetry elevated by wavelet decomposition and polarization-singular processing for analysis of specific cancerous tissue pathology.

Significance: Mueller-matrix polarimetry is a powerful method allowing for the visualization of malformations in biological tissues and quantitative evaluation of alterations associated with the progression of various diseases. This approach, in fact, is limited in observation of spatial localization and scale-selective changes in the poly-crystalline compound of tissue samples.

Aim: We aimed to improve the Mueller-matrix polarimetry approach by implementing the wavelet decomposition accompanied with the polarization-singular processing for express differential diagnosis of local changes in the poly-crystalline structure of tissue samples with various pathology.

The informativeness of the Johns-matrix image of laser autofluorescence in blood plasma films for early diagnosis of endometriosis associated with infertility.

We used Jones-matrix images of protein networks of blood plasma films obtained from laser autofluorescence and determined the sensitivity, specificity, accuracy, and prognostication of positive and negative results. Our study aimed (1) to develop and substantiate new approaches for the diagnosis of endometriosis by improving the methods of Jones-matrix mapping of laser-induced auto-fluorescence and (2) to develop statistical approaches for analyzing the distribution of values of the true component of Jones-matrix images of blood plasma. Biological preparations were performed for two groups: 35 samples from control group 1 (women with infertility of unknown origin) and 85 samples from group 2 with endometriosis (women with infertility and endometriosis).

State of hormonal balance in adolescent girls with menstrual function disorders associated with obesity.

Investigation of the mechanisms promoting the development of menstrual function disorders associated with obesity in adolescent girls is one of the most important issues of modern medicine. This study included 110 patients. 79 patients aged 12-18 with menstrual disorders associated with obesity were divided into two groups: group 1: 46 patients with apparent signs of hyperandrogenism, group 2: 33 patients without clinical manifestations of hyperandrogenism.

THE STUDY OF ACTION THE OZONE IN THE SURGICAL TREATMENT OF INFLAMMATORY PROCESSES BY DIABETES MELLITUS.

Objective: The aim: was to improve the course of purulent wounds in diabetes by using physical therapies.

Patients And Methods: Materials and methods: we investigated 122 patients with diabetes mellitus and wound processes. We divided all patients on the two groups.

The level of some hormones in the blood women with endometriosis which associated with infertility.

Objective: Introduction: The work has been dedicated the study of pituitary hormone concentration in the blood of women with endometriosis-associated infertility on 2-3 days of the menstrual cycle and the day of the puncture of ovarian stimulation superovulation in the cycle. The aim of our study was to examine the concentration of pituitary hormones in the blood of women with endometriosis associated with infertility.

Patients And Methods: Materials and methods: For the purpose of the research we have conducted a special study of protein (lutropin - LH, folitropin -FSH) hormones level in the blood plasma of women with endometriosis associated with infertility, which formed the main group of 20 people.

Peculiairities of the functioning circadian organization the ion-regulating function of kidney under the condition of pineal gland hyperfunction of the influence nitrogen monoxide synthesis blockade.

Objective: The aim of our work was to investigate the peculiarities of the functioning circadian organization the ion-regulating function of pineal gland hyperfunction of the influence nitrogen monoxide synthesis blockade.

Patients And Methods: Materials and methods: The experiments were conducted on 72 mature non-linear albino male rats with their body mass 0,15-0,18 kg. The control group included animals (n=36) kept under conditions of usual light regimen (12.

Peculiairities of the influence nitrogen monoxide synthesis blockade on circadian organization of kidney acid-regulating function under conditions of pineal gland hyperfunction.

Objective: Introduction: In recent decades chronobiology - a science that studies the regularities of the functioning of the organism, especially biological rhythms is developing rapidly. Biorhythms are stable nonstopper lifetime fluctuations with individual amplitude-frequency characteristics. Kidneys are characterized by a clear time organization of functions too, however, the peculiarities of circadian organization and the mechanisms of the participation of intracellular messengers in particular nitrogen monoxide (NО) in biorhythmic regulation of renal functions, remain insufficiently studied The aim of our work was to investigate the peculiairities of the influence nitrogen monoxide synthesis blockade on circadian organization of kidney acid-regulating function under conditions of pineal gland hyperfunction.

Circadian characteristic of kidney excretory function influenced by nitrogen monoxide synthesis blockade under conditions of pineal gland normal with peculiarities of melatonin effect.

Objective: The features of сhronorhythmic alterations of excretory renal function under the physiological conditions of the pineal gland (PG) under the influence of a blockade of synthesis of nitrogen monoxide (NO) and melatonin correction were investigated. The aim: Aim of our work was to investigate circadian characteristic of kidney excretory function influenced by nitrogen monoxide synthesis blockade under conditions of pineal gland normal with peguliarities of melatonin effect.

Patients And Methods: Materials and methods: The experiments were conducted on 72 mature non-linear albino male rats with their body mass 0,15-0,18 kg.

Application of ozone therapy in surgical practice.

Summarizing the review of literary sources, one can conclude that, despite a significant number of scientific papers devoted to the problem of pyoinflammatory complications of diabetes, there remain issues that require further study and solution. Taking into account the above facts, it becomes obvious that it is necessary to seek for more effective and advanced methods of complex treatment of pyoinflammatory complications of soft tissues, with an emphasis of search efforts on the introduction of effective therapeutic methods of conservative correction into the medical practice, methods of activation of reparative processes, aimed at restriction of invalidizating limb amputations, combined with further improvement of minimally invasive operational and technical innovations in the surgical direction.

Obesity during pregnancy: literature review.

Objective: Introduction: Maternal obesity is a serious problem in obstetric-gynecological practice in the world. Pathophysiological changes create conditions for obstetric and perinatal complications, the most important complications of which is gestational diabetes mellitus, preeclampsia, pathological course of labor, increased operative delivery, fetal distress. The aim of the study is to find out the depth of the problem "Obesity and Pregnancy" by analyzing the range of obstetric, perinatal complications based on the processing of scientific relevant literature data.

Obstetric and gynecological care by family doctors in ukraine: literature review.

Objective: Introduction: The analysis of literature on the questions of obstetrical and gynecologic care by general practitioners - family doctors in Ukraine has been presented in the article. Special attention has been paid to the actual problems of primary health care implementation on the basis of family medicine. The aim of the study is to find out the depth of the problem "A female doctor as an obstetrician-gynecologist" by analyzing scientific relevant literature data.