Setmelanotide in patients aged 2-5 years with rare MC4R pathway-associated obesity (VENTURE): a 1 year, open-label, multicenter, phase 3 trial.

Background: Setmelanotide, a melanocortin-4 receptor (MC4R) agonist, has been shown to reduce hunger and weight in patients aged 6 years and older with proopiomelanocortin (POMC) deficiency (including biallelic variants in proprotein convertase subtilisin/kexin type 1 [PCSK1]), leptin receptor (LEPR) deficiency, or Bardet-Biedl syndrome (BBS). No approved therapies for patients younger than 6 years old currently exist. The phase 3, open-label VENTURE trial aimed to evaluate the efficacy and safety of setmelanotide in patients aged 2-5 years with POMC or LEPR deficiency or BBS.

PET Imaging of Neurofibromatosis Type 1 with a Fluorine-18 Labeled Tryptophan Radiotracer.

Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder. Plexiform neurofibromas (PNFs) are benign tumors commonly formed in patients with NF1. PNFs have a high incidence of developing into malignant peripheral nerve sheath tumors (MPNSTs) with a 5-year survival rate of only 30%.

National debt management and business sustainability in Africa's largest economy: A focus on the private sector.

In many developing economies, high and increasing public debt profile constitutes an essential means of financial risk. An appropriate debt management is germane for survival of business and good international reputation though its effect on private sector credit mobilization had been seldomly investigated. This study seeks to know whether strategic debt management approach exacts a significant effect on the Nigerian private sector and Africa at large resulting to higher credit availability for sustainable enterprise establishment.

Information theory and thermodynamic properties of diatomic molecules using molecular potential.

Owing to the devise applications of molecules in industries, the bound state solution of the non-relativistic wave equation with a molecular potential function has been obtained in a closed-form using the Nikiforov-Uvarov method. The solutions of the bound state are then applied to study the information-theoretic measures such as the one-dimensional Shannon and Renyi entropic densities. The expectation values for the position and momentum spaces were obtained to verify the Heisenberg's uncertainty principle.

Legal responses to energy security and sustainability in Nigeria's power sector amidst fossil fuel disruptions and low carbon energy transition.

Fundamentally, energy could be refer to as the cornerstone for progress of most nations, as a lack of unswerving energy sources perpetuates poverty and impedes economic development. In Nigeria, there exists an abundance of low-carbon energy resources that hold immense potential for fostering sustainable growth. Regrettably, Nigeria has yet to fully harness these resources to drive its economic expansion and bolster its power sector.

Thermomagnetic properties and its effects on Fisher entropy with Schioberg plus Manning-Rosen potential (SPMRP) using Nikiforov-Uvarov functional analysis (NUFA) and supersymmetric quantum mechanics (SUSYQM) methods.

Thermomagnetic properties, and its effects on Fisher information entropy with Schioberg plus Manning-Rosen potential are studied using NUFA and SUSYQM methods in the presence of the Greene-Aldrich approximation scheme to the centrifugal term. The wave function obtained was used to study Fisher information both in position and momentum spaces for different quantum states by the gamma function and digamma polynomials. The energy equation obtained in a closed form was used to deduce numerical energy spectra, partition function, and other thermomagnetic properties.

Exact solutions of [Formula: see text]-dependent Schrödinger equation with quantum pseudo-harmonic oscillator and its applications for the thermodynamic properties in normal and superstatistics.

The effects of the curvature parameters on the energy eigenvalues and thermodynamic properties of quantum pseudoharmonic oscillator are investigated within the framework of nonrelativistic quantum mechanics. By employing Nikiforov-Uvarov method, the energy spectra are obtained and used to study the ordinary statistics and q-deformed superstatistics as a function of temperature in the presence and absence of the curvature parameters. It is shown that the q-deformed supertatistics properties of the quantum pseudoharmonic oscillator reduce to the ordinary statistical properties in the absence of the deformation parameter.

Tert-butylhydroquinone abrogates fructose-induced insulin resistance in rats via mitigation of oxidant stress, NFkB-mediated inflammation in the liver but not the skeletal muscle of high fructose drinking rats.

The effect of 21% fructose drinking water (FDW) (w/v) on some parameters of metabolic syndrome, hepatic, and skeletal muscular histology of rats was studied using standard techniques. Twenty male albino rats were divided into four groups of 5 rats each in this in vivo study. Group I received distilled water, group 2 received FDW, group 3 received FDW and metformin (300 mg/kg body weight daily, orally), group 4 received FDW and 1% tert-butylhydroquinone feed.

Analyzing the Effects of Topological Defect (TD) on the Energy Spectra and Thermal Properties of LiH, TiC and I Diatomic Molecules.

In this study, the impacts of TD on the energy spectra and thermal properties of , and diatomic molecules is considered. The Schrodinger equation in cosmic string spacetime is solved with the generalized Morse potential using the well-known (NU) method. The energy spectra and eigenfunction are obtained respectively.

Data set on moral values and parental primary school choice: A study of Ado-Odo Ota, Local Government Area, Ogun State.

The Nigerian society has been infiltrated with poor public and private schools due to underfunding by government and intervention of private individuals who prioritize profit over qualitative education. The implication is on quality of human capital in the country which interconnect with social and economic development. The dataset examine how parents selects schools for their wards and investigated the influence of socio-economic status, school academic reputation, moral reputation of school and location of school.

Pattern of comorbidities in school-aged children with cerebral palsy in Cross River State, Nigeria.

Background: To describe the pattern of comorbidities in school-aged children with cerebral palsy (CP) and to identify which, if any, were associated with poor school attendance. A cross-sectional study, using the key informant methodology, between December 2017 and July 2018 was conducted in Cross River State, Nigeria. Assessments, confirmation of CP and identification of systemic comorbidities using standard tools and questionnaires were performed.

Visual impairment and perceptual visual disorders in children with cerebral palsy in Nigeria.

Unlabelled: Cerebral palsy (CP) is the most common cause of childhood physical disability globally. This study describes the spectrum of ocular morbidity and visual impairment in a community-based (recruited by key informants) sample of children with CP in Cross River State, Nigeria.

Methods: A paediatric neurologist clinically confirmed CP and assessed systemic comorbidity.

Approximate energy spectra of improved generalized Mobius square potential (IGMSP) for some diatomic hydride molecules.

By employing the dissociation energy and equilibrium bond length as explicit parameters, we obtained the improved generalized Mobius square potential (IGMSP) model. We also defined the IGMSP parameters in terms of the molecular spectroscopic parameters. The IGMSP has been used to model inter-nuclear interaction potential curves for different diatomic hydrides.

Superstatistics of Schrödinger equation with pseudo-harmonic potential in external magnetic and Aharanov-Bohm fields.

In this work, the thermodynamic properties of pseudo-harmonic potential in the presence of external magnetic and Aharanov-Bohm fields are investigated. The effective Boltzmann factor in the superstatistics formalism was used to obtain the thermodynamic properties such as Helmholtz free energy, Internal energy, entropy and specific heat capacity of the system. In addition, the thermal properties of some selected diatomic molecules of and using their experimental spectroscopic parameters and the effect of varying the deformation parameter of were duly examined.

A unique indication for the senning procedure: Atrioventricular discordance with ventriculoarterial concordance.

Objective: We describe experience treating a patient with atrioventricular (AV) discordance with ventriculoarterial (VA) concordance, ventricular septal defect (VSD), and situs inversus. This is a rare congenital lesion in which closing the VSD would septate D-transposition physiology and performing an arterial switch and VSD closure would produce congenitally corrected transposition of the great arteries physiology. As such, it is the only lesion for which an isolated atrial switch (and VSD closure) remains the preferred correction.

Rotation-vibrational energies for some diatomic molecules with improved Rosen-Morse potential in D-dimensions.

By using the Nikiforov-Uvarov method, we solve the Schrödinger equation for the improved Rosen-Morse potential model in D spatial dimensions. We obtained the rotation-vibrational energies and the wave function, respectively. The ro-vibrational energies spectral of NO(aπ) and [Formula: see text] in D-dimensions have been computed by using the rotation-vibrational energy eigenvalues equation.

Thoraco-Abdominal Abnormalities in Bardet-Biedl Syndrome: Situs Inversus and Heterotaxy.

Objectives: To characterize the diversity and prevalence of thoraco-abdominal abnormalities in Bardet-Biedl syndrome (BBS), a model ciliopathy for understanding the role of cilia in human health.

Study Design: The Clinical Registry Investigating BBS, a worldwide registry exploring the phenotype and natural history of BBS, was used to conduct the study. Protected health information was obtained by subject or family interview and Health Insurance Portability and Accountability Act-approved release of data including imaging studies and genetic testing.

Bound state solutions of Schrödinger equation with modified Mobius square potential (MMSP) and its thermodynamic properties.

We solved the Schrödinger equation with the modified Mobius square potential model using the modified factorization method. Within the framework of the Greene-Aldrich approximation for the centrifugal term and using a suitable transformation scheme, we obtained the energy eigenvalues equation and the corresponding eigenfunction in terms of the hypergeometric function. Using the resulting eigenvalues equation, we calculated the vibrational partition function and other relevant thermodynamic properties.

Dataset on managerial incentives and bank performance: Evidence from Nigerian deposit money banks.

This study presents a data-set on the influence of managerial incentives on bank performance in selected Deposit Money Banks (DMB) in Nigeria. The use of managerial incentives to align interests of the principal and agent is advocated by agency theorists, but the peculiarity of the banking industry in terms of the role of regulation, capital structure, opacity and complexity of its transactions among others presents a different proposition in corporate governance research. The data collected over a longitudinal period between 2006 and 2016, provide information on specific managerial incentives and financial performance measures.

Correlation of ultrasonographic estimated fetal weight with actual birth weight in a tertiary hospital in Lagos, Nigeria.

Background: Sonographic fetal weight estimation is an important component of antenatal care.

Aim: To sonographically estimate fetal weight at term and to compare estimated with actual birth weights to determine the validity of estimated fetal weights.

Subjects And Methods: In the prospective study, a convenience sample of 282 women was recruited.

Nigerian Honey Ameliorates Hyperglycemia and Dyslipidemia in Alloxan-Induced Diabetic Rats.

Diabetic dyslipidemia contributes to an increased risk of cardiovascular disease. Hence, its treatment is necessary to reduce cardiovascular events. Honey reduces hyperglycemia and dyslipidemia.