Lymphaticovenular Anastomosis as a Treatment for Neurogenic Bladder in Patients With Lower Extremity Lymphedema After Gynecologic Cancer Treatment.

Background And Objectives: Neurogenic bladder (NB), a complication of gynecological cancer treatment, entails significant symptoms such as loss of urinary urgency, incontinence, and renal dysfunction. To investigate whether lymphatic fluid stagnation at the pelvis causes NB, we investigated the effectiveness of lymphaticovenular anastomosis (LVA) for NB.

Methods: In this retrospective study between 2014 and April 2024, LVA was performed on 52 patients complaining of preoperative urinary dysfunction with lower extremity lymphedema following pelvic lymphadenectomy in gynecologic cancer treatment.

Doubly Homologated Tyrosine-Containing Peptides from the Cyanobacterium NIES-4285 and Their Biosynthesis.

Chemical investigation of the cyanobacterium NIES-4285 led to the isolation of six new natural products, microginins 705 (), 719 (), 733A (), 733B (), and 733C (), and anabaenopeptin 885 (), and three known compounds, anabaenopeptins 871 (), B (), and F (). Planar structures and absolute configurations for - were determined by 2D NMR, HRMS, and Marfey's analyses. Microginin 733C (), and anabaenopeptins 871 () and 885 () contained a unique residue of 2-amino-5-(4-hydroxyphenyl)pentanoic acid (Ahppa): doubly homologated tyrosine (di-hTyr).

Antimicrobial and Cytotoxic Effect of Green Algae Isolate on MCF-7 Breast Cancer.

Introduction: Marine algae are increasingly becoming a potential resource for new drugs. In recent decades, including (). Meanwhile, antimicrobial and anticancer agents are the first line of choice for developing alternative compounds, considering the annually increasing resistant events.

Robust Pixel Design Methodologies for a Vertical Avalanche Photodiode (VAPD)-Based CMOS Image Sensor.

We present robust pixel design methodologies for a vertical avalanche photodiode-based CMOS image sensor, taking account of three critical practical factors: (i) "guard-ring-free" pixel isolation layout, (ii) device characteristics "insensitive" to applied voltage and temperature, and (iii) stable operation subject to intense light exposure. The "guard-ring-free" pixel design is established by resolving the tradeoff relationship between electric field concentration and pixel isolation. The effectiveness of the optimization strategy is validated both by simulation and experiment.

The Success Rate Is Lower but Completion Rate of Laparoscopic Cholecystectomy Is higher in Endoscopic Transpapillary Gallbladder Drainage than Percutaneous Gallbladder Drainage for Acute Cholecystitis.

Background: We investigated the success and complication rates of endoscopic transpapillary gallbladder drainage (ETGBD) and percutaneous transhepatic gallbladder drainage (PTGBD) and the outcomes of subsequent cholecystectomy for acute cholecystitis.

Methods: Patients (N=178) who underwent cholecystectomy after ETGBD or PTGBD were retrospectively assessed.

Results: ETGBD was successful in 47 (85.

Subtle radiographic progression at 6 months can be detected using automated quantitative software in rheumatoid arthritis while receiving tocilizumab.

Objectives: We investigated whether our in-house software equipped with partial image phase-only correlation (PIPOC) can detect subtle radiographic joint space narrowing (JSN) progression at 6 months and predict JSN progression in rheumatoid arthritis (RA) patients receiving Tocilizumab.

Methods: The study included 39 RA patients who were treated with Tocilizumab. Radiological progression of the finger joints was evaluated according to the Genant-modified Sharp score (GSS) at 0, 6, and 12 months.

Noducyclamides A1-A4, B1, and B2 from the Cyanobacterium sp. NIES-3585.

A chemical investigation of the hydrophilic fraction of a cultured sp. (NIES-3585) afforded six new cyclic lipopeptides, noducyclamides A1-A4 (-) containing 10 amino acid residues and dodecapeptides noducyclamides B1 and B2 ( and ). The planar structures of these lipopeptides were elucidated based on the combination of HRMS and 1D and 2D NMR spectroscopic data analyses.

Cyanoremediation of heavy metals (As(v), Cd(ii), Cr(vi), Pb(ii)) by live cyanobacteria (, and sp.): an eco-sustainable technology.

The cyanoremediation technique for heavy metal (HM) removal from wastewater using live cyanobacteria is promising to reduce the pollution risk both for the environment and human health. In this study, two widely recognized freshwater cyanobacteria, and sp., were used to explore their efficacy in HM (As(v), Cd(ii), Cr(vi), Pb(ii)) removal.

[Up to Date of Cyanobacterial Natural Products].

More than 2000 compounds have been reported from cyanobacteria. The most successful example is dolastatin 10, of which a related compound monomethylauristatin E is used as antibody-drug conjugate (ADC) for Hodgkin lymphoma and systemic anaplastic large cell lymphoma. Recently genome-based analyses by Piel led to the discovery of novel compounds from cyanobacteria.

Successful management of malignant colovesical fistula using covered colonic self-expanding metallic stent: a case report.

Background: A colovesical fistula (CVF) is commonly treated by resection of the intestine containing the fistula or creation of a defunctioning stoma. We herein report a case of successful fistula closure and avoidance of colostomy after placement of a covered colonic self-expanding metallic stent (SEMS) as a palliative treatment for a malignant CVF.

Case Presentation: A 75-year-old man undergoing infusional 5-fluorouracil and irinotecan chemotherapy plus bevacizumab for recurrent peritoneal dissemination of rectal cancer was admitted to our hospital because of fecaluria with a high-grade fever.

A deep registration method for accurate quantification of joint space narrowing progression in rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that leads to progressive articular destruction and severe disability. Joint space narrowing (JSN) has been regarded as an important indicator for RA progression and has received significant attention. Radiology plays a crucial role in the diagnosis and monitoring of RA through the assessment of joint space.

Syntheses and Biological Activities of Danicalipin A Derivatives.

Synthesis of three derivatives of danicalipin A, tetrachloride, trisulfate and a fluorescent probe was achieved through Wittig reaction strategy. Toxicity of the derivatives against brine shrimp (Artemia salina) as also investigated to provide useful information for the biological activity; i) less chloride derivative showed similar toxicity to danicalipin A, ii) the amphiphilic property, a characteristic feature of danicalipin A, was crucial because trisulfate considerably decreased the toxicity and iii) fluorescent derivative kept brine shrimp toxicity of danicalipin A.

[Traumatic Neuroma Mimicking Lymph Node Metastasis of Pancreatic Neuroendocrine Neoplasms Developed after Pancreatoduodenectomy-A Case Report].

A traumatic neuroma is a benign tumor consisting of a non-neoplastic growth of injured nerves as a result of trauma or surgery. It is rarely found in an abdominal cavity, but some reports showed that it occurred around the bile duct. We report a case of a 72-year-old man who underwent subtotal stomach-preserving pancreatoduodenectomy for pancreatic neuroendocrine neoplasms 4 years ago.

Development of Targeted Protein-Displaying Technology with a Novel Carbon Material.

This study reports a new carbon material and its specific display of targeted protein. The properties of the carbon materials fabricated with carbon black MOGUL were analyzed. The carbon materials were spherical structures with 55.

Fully automatic software for detecting radiographic joint space narrowing progression in rheumatoid arthritis: phantom study and comparison with visual assessment.

Purpose: We have developed an in-house software equipped with partial image phase-only correlation (PIPOC) which can automatically quantify radiographic joint space narrowing (JSN) progression. The purpose of this study was to evaluate the software in phantom and clinical assessments.

Materials And Methods: In the phantom assessment, the software's performance on radiographic images was compared to the joint space width (JSW) difference using a micrometer as ground truth.

[A case of rectovaginal metastasis 6 years after initial resection of extra-gastrointestinal stromal tumor of vulvar origin].

A 53-year-old woman who had undergone excision of KIT-positive extra-gastrointestinal stromal tumor (EGIST) of the vulva 6 years ago presented to our hospital due to a positive fecal occult blood test. Colonoscopy revealed a submucosal tumor in the rectum ventral side. In addition, computed tomography and magnetic resonance imaging revealed a tumor in the rectovaginal septum.

Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation.

Protein S-acylation is a reversible post-translational modification that modulates the localization and function of many cellular proteins. S-acylation is mediated by a family of zinc finger DHHC (Asp-His-His-Cys) domain-containing (zDHHC) proteins encoded by 23 distinct ZDHHC genes in the human genome. These enzymes catalyze S-acylation in a two-step process involving "autoacylation" of the cysteine residue in the catalytic DHHC motif followed by transfer of the acyl chain to a substrate cysteine.

Nostosin G and Spiroidesin B from the Cyanobacterium sp. NIES-1697.

Chemical investigation of the cyanobacterium sp. NIES-1697 afforded nostosin G (), a linear tripeptide, spiroidesin B (), and two known compounds, anabaenopeptins I () and J (). Planar structures and absolute configurations for and were determined by 2D NMR, HRMS, Marfey's methodology, chiral-phase HPLC, and enzymatic degradation.

Thiol-disulfide oxidoreductase PDI1;1 regulates actin structures in Oryza sativa root cells.

The polarized and dynamic actin cytoskeleton is essential for root cell growth. Here, we report the key role of thiol-disulfide oxidoreductase PDI1;1 in actin structures. Microscopic analyses revealed that after Oryza sativa roots were exposed to H O , both actin and PDI1;1 were depolarized and arranged in a meshwork.

C-reactive protein level on postoperative day 3 as a predictor of anastomotic leakage after elective right-sided colectomy.

Purpose: To investigate the factors predictive of anastomotic leakage in patients undergoing elective right-sided colectomy.

Methods: The subjects of this retrospective study were 247 patients who underwent elective right hemicolectomy or ileocecal resection with ileocolic anastomosis between April 2012 and March 2019, at our institution.

Results: Anastomotic leakage occurred in 9 of the 247 patients (3.

Argicyclamides A-C Unveil Enzymatic Basis for Guanidine Bis-prenylation.

Guanidine prenylation is an outstanding modification in alkaloid and peptide biosynthesis, but its enzymatic basis has remained elusive. We report the isolation of argicyclamides, a new class of cyanobactins with unique mono- and bis-prenylations on guanidine moieties, from NIES-88. The genetic basis of argicyclamide biosynthesis was established by the heterologous expression and characterization of biosynthetic enzymes including AgcF, a new guanidine prenyltransferase.

Predictive model for postoperative pleural effusion after hepatectomy.

Aim: Severe postoperative pleural effusion (sPOPE) after hepatectomy can lead to respiratory distress and may require thoracic drainage, leading to prolonged hospitalization. Preventive chest tube insertion may be useful for patients at high risk for sPOPE. We aimed to develop a predictive model for sPOPE after hepatectomy and evaluate indications for preventive chest tube insertion using our model.

A case of human breast sparganosis diagnosed as Spirometra Type I by molecular analysis in Japan.

A 92-year-old Japanese woman presented with a mass in the left breast, and sparganosis was suspected by biopsy of the mass. The mass disappeared once, but it reappeared at the same site one year later. For a definitive diagnosis, the mass was surgically removed, and a sparganum-like worm was detected.

How to treat remnant cholecystitis after subtotal cholecystectomy: two case reports.

Background: Subtotal cholecystectomy in patients with severe acute cholecystitis is considered a "bailout" option when the safety of the bile duct cannot be guaranteed. However, subtotal cholecystectomy has a long-term risk of remnant cholecystitis. The appropriate management of remnant cholecystitis has not been fully elucidated.