Publications by authors named "Okekunle A"

Article Synopsis
  • The study aimed to investigate how alcohol consumption is linked to stroke occurrences in Nigeria and Ghana by comparing individuals who had strokes to those who didn't.!
  • It involved over 7,368 participants, classifying them into groups based on their alcohol consumption habits, and utilized various statistical models to analyze the data.!
  • Results indicated that current drinkers had a higher risk of stroke, particularly among moderate, binge, and heavy drinkers, while former drinkers showed no significant stroke risk. !
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Hypertension is a major risk factor for cardiovascular events worldwide, and little is known about its association with sleep quality (SQ) among Africans. We evaluated the association of SQ with hypertension among adults in Ibadan, Nigeria. In Ibadan and its suburbs, we identified 3635 participants in the door-to-door Community-based Investigation of the Risk Factors for Cardiovascular Diseases (COMBAT-CVDs) study.

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Background: The sleep quality scale (SQS) is a comprehensive multidimensional sleep assessment scale used to evaluate sleep quality (SQ) among adults in the general population. However, the scale is yet to be validated among indigenous African populations such as in Nigeria. This study validated the factor structure and evaluated the reliability of a previously developed SQS among community-based adults in Ibadan, Nigeria.

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  • This study developed a Sustainable Diet Index (SDI) to assess the sustainability of diets among adults in Ghana and Ghanaian migrants in Europe, focusing on factors like health, climate impact, cultural values, and cost.
  • Using data from 3,169 participants aged 25-70, the SDI ranged from 0 to 16 and utilized various dietary metrics, showing an overall mean SDI of 8.0.
  • Results indicated that higher SDI scores were linked to older age, female gender, non-smoking, and alcohol abstinence, with the highest SDI found in London (9.1), suggesting that living in Europe generally leads to more sustainable dietary practices compared to rural Ghana.
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  • * The research involved 1,793 individuals, including adenoma patients and healthy controls from a health check-up at a Korean hospital, analyzing their fish and meat consumption through dietary questionnaires.
  • * Results indicated that while there wasn't a clear link between general meat consumption and adenoma prevalence, higher fish intake correlated with a lower risk of high-risk colorectal adenomas, particularly more significantly in men.
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Introduction: Leveraging data science could significantly advance the understanding of the health impacts of climate change and air pollution to meet health systems' needs and improve public health in Africa. This scoping review will aim to identify and synthesise evidence on the use of data science as an intervention to address climate change and air pollution-related health challenges in Africa.

Methods And Analysis: The search strategy will be developed, and the search will be conducted in the Web of Science, Scopus, CAB Abstracts, MEDLINE and EMBASE electronic databases.

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Background: Prediction algorithms/models are viable methods for identifying individuals at high risk of stroke across diverse populations for timely intervention. However, evidence summarizing the performance of these models is limited. This study examined the performance and weaknesses of existing stroke risk-score-prediction models (SRSMs) and whether performance varied by population and region.

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Background: Hypertension is preeminent among the vascular risk factors for stroke occurrence. The wide gaps in awareness, detection, treatment, and control rates of hypertension are fueling an epidemic of stroke in sub-Saharan Africa.

Purpose: To quantify the contribution of untreated, treated but uncontrolled, and controlled hypertension to stroke occurrence in Ghana and Nigeria.

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The prevalence of hypertension, the commonest risk factor for preventable disability and premature deaths, is rapidly increasing in Africa. The African Control of Hypertension through Innovative Epidemiology, and a Vibrant Ecosystem [ACHIEVE] conference was convened to discuss and initiate the co-implementation of the strategic solutions to tame this burden toward achieving a target of 80% for awareness, treatment, and control by the year 2030. Experts, including the academia, policymakers, patients, the WHO, and representatives of various hypertension and cardiology societies generated a 12-item communique for implementation by the stakeholders of the ACHIEVE ecosystem at the continental, national, sub-national, and local (primary) healthcare levels.

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Article Synopsis
  • African ancestry populations have the highest stroke burden globally, yet the genetic factors contributing to stroke in these groups are not well understood, prompting the SIREN study in West Africa to investigate this.
  • The study involved recruiting stroke patients and stroke-free controls to conduct a genome-wide association study (GWAS), leading to DNA analysis that identified significant SNPs near specific genes associated with stroke risk.
  • Key findings highlighted protective genetic variants near AADACL2 and MIR5186 on chromosome 3, as well as other notable associations on chromosomes 5, 6, 12, 16, and 18, which could provide insights for future stroke risk assessment in these populations.
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Purpose: Sleep quality (SQ) is essential in the overall well-being and quality of life, but little is known about the association of secondhand smoking (SHS) with SQ. This study assessed the relationship between SHS and SQ among adults who had never smoked in Ibadan, Nigeria.

Methods: We identified 3193 respondents who had never smoked or used any form of tobacco product in the Community-based Investigation of the Risk Factors for Cardiovascular Diseases in the Ibadan and suburbs (COMBAT-CVDs) study.

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Background: The dietary factors associated with the high burden of hypertension among indigenous Africans remain poorly understood. We assessed the relationship between dietary patterns and hypertension among indigenous Africans.

Method: In this study, 1550 participants with hypertension matched (for age: ± 5 years, sex and ethnicity) with 1550 participants without hypertension were identified from the stroke-free population in the Stroke Investigative Research and Educational Network study in Ghana and Nigeria.

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Background: Frequent fruit and vegetable consumption is considered a promising dietary behaviour that protects health. However, most existing studies about the factors associated with this phenomenon among Africans are based on single-country reports, apart from one meta-regression combining smaller studies. This study harmonized large datasets and assessed factors associated with the frequency of fruit and vegetable consumption in this population.

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  • The study explored how diagnosed high blood pressure (HBP) relates to closeness to healthcare and noise sources in Ibadan, Nigeria, focusing on various sociodemographic and economic factors.
  • Researchers analyzed data from 13,531 adults using GIS to map locations of key community facilities and health diagnoses, finding significant links between HBP and proximity to pharmacies, religious institutions, and major roads.
  • The findings revealed that being unemployed, married, and having higher educational levels increased the odds of having diagnosed HBP, suggesting that reducing noise pollution might help lower hypertension rates in urban areas.
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Background: Spontaneous intracerebral hemorrhage (ICH) is associated with a high case fatality rate in resource-limited settings. The independent predictors of poor outcome after ICH in sub-Saharan Africa remains to be characterized in large epidemiological studies. We aimed to determine factors associated with 30-day fatality among West African patients with ICH.

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Article Synopsis
  • Non-cigarette tobacco (NCT) use is linked to an increased risk of stroke among indigenous Africans, suggesting a need for better understanding and public health interventions.
  • The study involved 7,617 respondents, showing that those who used smokeless NCT had a significant association with stroke, while smoked NCT did not show a strong link.
  • Increased awareness and targeted policies are essential to address the rising burden of stroke related to NCT usage in the population.
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Objectives: This study assessed the association between alcohol use patterns and the prevalence of hypertension.

Study Design: Data on alcohol use patterns and hypertension among 5918 adults from the 2015-2016 National Health and Nutrition Examination Survey was used for this study.

Methods: The association of alcohol use patterns; "ever-used alcohol", "binge drinking", "heavy drinking", and "everyday alcohol use" with hypertension were assessed using multivariable-adjusted logistic regression to estimate the adjusted odds ratio (aOR) and 95% confidence interval (CI) at a two-sided P < 0.

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Background: Non-alcoholic fatty liver disease (NAFLD) is a major contributor to liver diseases globally, yet there are limited studies investigating the impact of diet and lifestyle factors on its development. This study aimed to examine the association between the prevalence of NAFLD and predicted pro-inflammatory high-sensitivity C-reactive protein (hs-CRP) score.

Methods: We included 1,076 Korean adults who underwent a medical examination at the Seoul National University Hospital Gangnam Healthcare Center in Korea between May and December 2011 and updated in 2021.

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Background: This study aimed to develop a risk-scoring model for hypertension among Africans.

Methods: In this study, 4413 stroke-free controls were used to develop the risk-scoring model for hypertension. Logistic regression models were applied to 13 risk factors.

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Background/objectives: Habitual coffee consumption was inversely associated with type 2 diabetes (T2D) and hyperglycemia in observational studies, but the causality of the association remains uncertain. This study tested a causal association of genetically predicted coffee consumption with T2D using the Mendelian randomization (MR) method.

Subjects/methods: We used five single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) associated with habitual coffee consumption in a previous genome-wide association study among Koreans.

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Background: The potential role of dietary branched-chain amino acids (BCAA) in metabolic health, including cardiovascular disease and diabetes, is evolving, and it is yet to be understood if dietary BCAA intakes are associated with plasma lipid profiles or dyslipidaemia. This study tested the association of dietary BCAA intakes with plasma lipid profiles and dyslipidaemia among Filipino women in Korea.

Methods: Energy-adjusted dietary BCAA intakes (isoleucine, leucine, valine, and total BCAA) and fasting blood profiles of triglycerides (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) were determined in a sample of 423 women enrolled in the Filipino Women's Diet and Health Study (FiLWHEL).

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Article Synopsis
  • Background research indicates that severe stroke outcomes in sub-Saharan Africa may be linked to initial stroke severity, but there is limited knowledge on what influences stroke severity specifically in indigenous Africans.
  • A study involving 3,660 West African stroke cases found that diet (high meat and low vegetable consumption) and lesion volume significantly correlated with severe stroke conditions, with severe cases comprising over half of all evaluated strokes.
  • The findings suggest that addressing dietary habits and understanding lesion characteristics could help mitigate the high rates of severe stroke in this population.
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Hypertension is a leading preventable and controllable risk factor for cardiovascular and cerebrovascular diseases and the leading preventable risk for death globally. With a prevalence of nearly 50% and 93% of cases uncontrolled, very little progress has been made in detecting, treating, and controlling hypertension in Africa over the past thirty years. We propose the African Control of Hypertension through Innovative Epidemiology and a Vibrant Ecosystem (ACHIEVE) to implement the HEARTS package for improved surveillance, prevention, treatment/acute care of hypertension, and rehabilitation of those with hypertension complications across the life course.

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Unlabelled: Previous epidemiological studies demonstrated an increased risk of respiratory health effects in children and adults exposed to dampness or mold. This study investigated associations of quantitative indicators of indoor dampness and mold exposure with severe lower respiratory tract infections (LRTI) among children aged 1-59 months in Ibadan, Nigeria.

Methods: In-home visits were conducted among 178 children hospitalized with LRTI matched by age (±3 months), sex, and geographical location with 180 community-based children without LRTI.

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