Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs.

This study aimed to investigate the in vitro performance of self-nanoemulsifying drug delivery systems (SNEDDSs) of Ornidazole (ORD), a poorly water-soluble drug. Self-nanoemulsifying drug delivery systems of ORD were prepared using various oils, non-ionic surfactants, and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of ORD in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading.

Ingestion exposure of public to natural radionuclides and committed effective dose and cancer risk through tuber crops cultivated in Ebonyi State, Nigeria.

Internal exposure of public to radiation arising from ingestion of natural radionuclides in tuber crops of Ebonyi State origin was investigated in this study. Committed effective doses and lifetime cancer risk of K, Ra, and Th in cassava, cocoyam, water yam, and white yam were calculated. The average activity concentrations of K, Ra, and Th determined by gamma spectrometric Na (TI) detector were, respectively, 199.