Capsid display of a conserved human papillomavirus L2 peptide in the adenovirus 5 hexon protein: a candidate prophylactic hpv vaccine approach.

Background: Infection by any one of 15 high risk human papillomavirus (hrHPV) types causes most invasive cervical cancers. Their oncogenic genome is encapsidated by L1 (major) and L2 (minor) coat proteins. Current HPV prophylactic vaccines are composed of L1 virus-like particles (VLP) that elicit type restricted immunity.

Outcomes in Ovarian Cancer among Hispanic Women Living in the United States: A Population-Based Analysis.

Introduction. Ovarian cancer is the deadliest gynecologic cancer in the United States. There is limited data on presentation and outcomes among Hispanic women with ovarian cancer.

Introduction of checklists at daily progress notes improves patient care among the gynecological oncology service.

Objectives: To evaluate the impact of the introduction of checklists at the daily progress note to improve patient care among gynecologic oncology patients.

Methods: A progress note incorporating checklists that were pertinent for our patient population was developed with input obtained from all staff involved on patients care. The form was approved by the hospital.

Sexual activity and function in women with and without pelvic floor disorders.

Introduction And Hypothesis: We describe differences in sexual activity and function in women with and without pelvic floor disorders (PFDs).

Methods: Heterosexual women ≥40 years of age who presented to either urogynecology or general gynecology clinics at 11 clinical sites were recruited. Women were asked if they were sexually active with a male partner.

The risk of umbilical hernia and other complications with laparoendoscopic single-site surgery.

Study Objective: To estimate the risk of umbilical hernia and other latent complications in women who underwent laparoendoscopic single-site surgery (LESS) for a gynecologic indication.

Design: Retrospective, nonrandomized clinical study (Canadian Task Force classification II-2).

Setting: Four tertiary care academic medical centers.

Analysis of racial disparities in stage IIIC epithelial ovarian cancer care and outcomes in a tertiary gynecologic oncology referral center.

Objective: To examine disparities in delivery of care and survival according to racial classification among White and African-American women with Stage IIIC epithelial ovarian cancer undergoing initial treatment in a tertiary referral center setting.

Methods: All consecutive patients diagnosed with Stage IIIC epithelial ovarian cancer between 1/1/95 and 12/31/08 were identified and clinic-pathologic variables retrospectively collected. Differences in initial treatment paradigm, surgical and adjuvant therapy, and overall survival according to racial classification were assessed by univariate and multivariate analyses.

Hormone replacement therapy in gynecologic cancer survivors: why not?

Purpose: As a result of treatment, many women with gynecologic malignancies will go through menopause and display climacteric symptoms at an earlier age than occurs naturally. Iatrogenic menopause may adversely affect quality of life and health outcomes in young female cancer survivors. Hormone replacement therapy (HRT) has often been withheld from women with gynecologic cancer because of concern that it might increase the risk of relapse or the development of new primary cancers.

Racial disparities in ovarian cancer surgical care: a population-based analysis.

Objective: To investigate differences according to racial classification in the frequency of ovarian cancer-related surgical procedures and in access to high-volume surgical providers among women undergoing initial surgery for ovarian cancer.

Methods: The Maryland Health Services Cost Review Commission database was accessed for women age >18years undergoing a surgical procedure that included oophorectomy for a malignant ovarian neoplasm between 7/1/01 and 6/30/09. Multivariate logistic regression analyses were used to evaluate for differences in the likelihood of selected surgical procedures and access to high-volume surgical providers (surgeons≥10 cases/year; hospitals≥20 case/year) according racial classification.

Molecular pathogenesis of cervical cancer.

Introduction: Cervical cancer is a sexually transmitted disease that results from infection with oncogenic types of human papillomavirus (HPV). Oncogenic HPV DNA is found in over 95% of invasive cervical cancers worldwide. Cervical cancer is a leading cause of cancer deaths in developing countries because of high HPV infection rates and lack of comprehensive cervical Pap smear testing of susceptible women.

Laparoendoscopic single-site surgery (LESS) in gynecology: a multi-institutional evaluation.

Objective: The study objectives were to determine the surgical outcomes of a large series of gynecology patients treated with laparoendoscopic single-site surgery (LESS).

Study Design: This was a retrospective, multi-institutional analysis of gynecology patients treated with LESS in 2009. Patients underwent surgery via a single 1.

Hypertrophic cervical elongation: clinical and histological correlations.

Introduction And Hypothesis: The objective of this study is to define the diagnosis of hypertrophic cervical elongation clinically and to perform histochemical and histological evaluations of patients with and without hypertrophic cervical elongation.

Methods: This prospective study was conducted at Louisiana State University between December 2005 and May 2008. Fourteen women with cervical elongation and 28 women without prolapse were studied.

Predicting the outcome of cytoreductive surgery for advanced ovarian cancer: a review.

Introduction: Ovarian cancer is the leading cause of gynecologic cancer-related mortality in the United States. Surgical cytoreduction is the cornerstone of current treatment in patients with advanced disease, but it offers the best chances for overall survival when optimal cytoreduction is achieved. Clinicopathological and radiological models for predicting optimal resectability have not been universally applicable.

Does vaginal size impact sexual activity and function?

Introduction And Hypothesis: This study seeks to determine if total vaginal length (TVL) or genital hiatus (GH) impact sexual activity and function.

Methods: Heterosexual women >or= 40 years were recruited from urogynecology and gynecology offices. TVL and GH were assessed using the Pelvic Organ Prolapse Quantification exam.

Complications of transvaginal monofilament polypropylene mesh in pelvic organ prolapse repair.

Introduction And Hypothesis: This study aimed to document intraoperative and postoperative complications associated with the use of transvaginal polypropylene mesh in the repair of pelvic organ prolapse (POP).

Methods: This is a retrospective review of 127 cases of transvaginal repair of POP using synthetic mesh.

Results: Mean postoperative value (+/-SD) for pelvic organ prolapse quantification (POPQ) measurements Aa, Ap, and C were: -2.

Urinary tract injury during hysterectomy based on universal cystoscopy.

Objective: To estimate the incidence and location of injury to the urinary tract during hysterectomy for benign gynecologic disease.

Methods: This was a prospective clinical study in an academic environment performed at three sites. Diagnostic cystourethroscopy was performed on all patients after hysterectomy for benign disease.